ROLE OF CYTOKINES IN THE DEVELOPMENT OF LIVER CIRRHOSIS, WHICH DEVELOPED AS A RESULT OF CHRONIC VIRAL HEPATITIS D
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Under conditions of inefficient SGD elimination, phenotypic activated lymphocytes that change in the course of infection chronicling form cytokines with profibrosis effects, which then trigger fibroblasts, endothelial cells, stellacites, as well as cause the marrow-derived recirculating cells to transform into myofibroblasts as well as the development of liver fibrosis. Cytokines are soluble proteins that are developed by a wide range of cells, primarily Th1 and Th2 type cells. These lymphocytes are able to recognize cells damaged by the virus and directly and indirectly control the strength of the immunological and inflammatory response. In chronic viral hepatitis, the formation of cytokines and their levels are described as impaired due to the persistence of viruses.
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