TRACE ELEMENTS AND SARS-COV-2 INFECTION: A SYSTEMATIC REVIEW OF CLINICAL TRIALS
Аннотация
Background: Trace elements such as copper, zinc, magnesium, etc. are the minerals present in living tissues in small concentrations, which primarily act as catalysts in the enzyme system. Literature has indicated the role and alteration of trace elements in viral infections. However, the role of trace elements in SARS-CoV-2 infection is unclear so far. Aim: The aim of the study was to perform a systematic review to find out the role of trace elements in SARS-CoV-2 infection as well as the effect of SARS-CoV-2 infection on trace elements. Material and Method: The relevant studies were searched in PubMed and clinical trial websites, and screened based on inclusion and exclusion criteria. The quality of studies was assessed using NIH quality assessment tools. Results: A total of 19 studies were found relevant after screening 23,570 studies. The level of zinc was found to be decreased, the level of magnesium was found to be altered, and the level of copper was found to be increased after SARS-CoV-2 infection. Conclusion: Thus, supplementation of a particular trace element can be useful as an add-on therapy for COVID-19 infection. Further, more studies are required to find out the exact role of these elements in COVID-19 infection.
Библиографические ссылки
D. Cucinotta, M. Vanelli, WHO Declares COVID-19 a Pandemic, Acta. Biomed. 91(2020) 157-160. https://doi.org10.23750/abm.v91i1.9397
World Health Organization, WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int/ (Accessed 8 September 2021)
Centers for Disease Control and Prevention, Coronavirus Disease 2019 (COVID-19) – Symptoms.
https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html> (Accessed 5 September 2021).
B. de Almeida-Pititto, P.M. Dualib, L. Zajdenverg et al., Severity and mortality of COVID 19 in patients with diabetes, hypertension and cardiovascular disease: a meta-analysis, Diabetol. Metab. Syndr. 12, 75 (2020). https://doi.org/10.1186/s13098-020-00586-4
A. Sanyaolu, C. Okorie, A. Marinkovic et al., Comorbidity and its Impact on Patients with COVID-19, SN. Compr. Clin. Med. (2020)1-8. https://doi.org/10.1007/s42399-020-00363-4
National Research Council (US) Committee on Diet and Health, Diet and Health: Implications for Reducing Chronic Disease Risk, Washington (DC): National Academies Press (US); 1989. 14, Trace Elements. https://www.ncbi.nlm.nih.gov/books/NBK218751/
M. Jarosz, M. Olbert, G. Wyszogrodzka, K. Młyniec, and T. Librowski, T., 2017, Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling. Inflammopharmacology. 25(1(2017) 11-24.
AS. Prasad, Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health, Front. Nutr. (2014)1:14. https://doi.org/10.3389/fnut.2014.00014
N.A. Tayyib, P. Ramaiah, F.J. Alsolami, M.S. Alshmemri MS, Immunomodulatory effects of zinc as a supportive strategies for COVID-19, Journal of Pharmaceutical Research International. 1(2020) 14-22.
S.A. Read, S. Obeid, C. Ahlenstiel, G. Ahlenstiel, The Role of Zinc in Antiviral Immunity, Advances in Nutrition. 10(2019) 696–710, https://doi.org/10.1093/advances/nmz013
K. Yuasa, A Naganuma, K. Sato, M. Ikeda, N. Kato, H Takagi, M. Mori, Zinc is a negative regulator of hepatitis C virus RNA replication, Liver Int. 26(9(2006) 1111-8. https://doi.org/10.1111/j.1478-3231.2006.01352.x
M. Lazarczyk, C. Pons, J.A. Mendoza, P. Cassonnet, Y. Jacob, M. Favre, Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses, J. Exp. Med. 21;205(1(2008):35-42. https://doi.org/10.1084/jem.20071311
Y. Haraguchi, H. Sakurai, S. Hussain, B.M. Anner, H. Hoshino, Inhibition of HIV-1 infection by zinc group metal compounds, Antiviral Res. 43(2(1999) 123-33. https://doi.org/10.1016/s0166-3542(99)00040-6
M. Bost, S. Houdart, M. Oberli, E. Kalonji, JF. Huneau, I. Margaritis, Dietary copper and human health: Current evidence and unresolved issues, J Trace Elem Med Biol. 35(2016)107-115. https://doi.org/10.1016/j.jtemb.2016.02.006
A. Andreou, S. Trantza, D.Filippou, N. Sipsas, S. Tsiodras, COVID-19: The Potential Role of Copper and N-acetylcysteine (NAC) in a Combination of Candidate Antiviral Treatments Against SARS-CoV-2, In Vivo. 34(3(2020) 1567-1588. https://doi.org/10.21873/invivo.11946
K. Agin, & M. Moinazad Tehrany, Status Trace Elements of Zinc, Magnesium and Calcium Electrolytes in Serum, International Journal of Medical Toxicology and Forensic Medicine. 2(1(winter)), (2021) 6-12. https://doi.org/10.22037/ijmtfm.v2i1(winter).2959
H. Tapiero, D. M. Townsend, and K. D. Tew, The antioxidant role of selenium and seleno-compounds, Biomedicine & pharmacotherapy. 57(3-4) (2003) 134-144. https://doi.org/10.1016/S0753-3322(03)00035-0
L. Duntas, Selenium and inflammation: underlying anti-inflammatory mechanisms, Hormone and metabolic research. 41(06) (2009) 443-447. https://doi.org/10.1055/s-0029-1220724
D. Moher, A. Liberati, J. Tetzlaff, D.G. Altman, The PRISMA Group (2009) Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement, PLoS Med 6(7)(2009) e1000097. https://doi.org/10.1371/journal.pmed.1000097
C.W. Tan, L.P. Ho, S. Kalimuddin, et al., Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19), Nutrition. (2020)79-80 111017. https://doi.org/10.1016/j.nut.2020.111017
D. Quilliot, O. Bonsack, R. Jaussaud, A. Mazur, Dysmagnesemia in Covid-19 cohort patients: prevalence and associated factors, Magnes Res. 33(4(2020) 114-122. https://doi.org/10.1684/mrh.2021.0476
S.S. Jacob, A.M. Andrew, L.N. Thomas, A.H. Syed, M. Sumit, Increased Mortality Associated with Hypermagnesemia in Severe COVID-19 Illness, Kidney360. 2 (7(2021) 1087-1094; https://doi.org/10.34067/KID.0002592021
R.A. Heller, Q. Sun, J. Hackler et al., Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker, Redox Biol. 38(2021)101764. https://doi.org/10.1016/j.redox.2020.101764
O.B. Pour, Y. Yahyavi, A. Karimi et al., Serum trace elements levels and clinical outcomes among Iranian COVID-19 patients, Int. J. Infect. Dis. S1201-9712(2021). https://doi.org/10.1016/j.ijid.2021.08.053
A.S. Elham, K. Azam, J. Azam, L. Mostafa, B. Nasrin, N. Marzieh, Serum vitamin D, calcium, and zinc levels in patients with COVID-19, Clin. Nutr. ESPEN. 43(2021)276-282. https://doi.org/10.1016/j.clnesp.2021.03.040
H. Elalfy, T. Besheer, A. El-Mesery et al., Effect of a combination of nitazoxanide, ribavirin, and ivermectin plus zinc supplement (MANS.NRIZ study) on the clearance of mild COVID-19, J. Med. Virol. 93(5(2021) 3176-3183. https://doi.org/10.1002/jmv.26880
R. Derwand, M. Scholz, V. Zelenko, COVID-19 outpatients: early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: a retrospective case series study, Int. J. Antimicrob. Agents. 56(6(2020) 106214. https://doi.org/10.1016/j.ijantimicag.2020.106214
O. Patel, V. Chinni, J. El‐Khoury et al., A pilot double‐blind safety and feasibility randomized controlled trial of high‐dose intravenous zinc in hospitalized COVID‐19 patients, J. Med. Virol. 93(2021) 3261‐3267. https://doi.org/10.1002/jmv.26895
S. Thomas, D. Patel, B. Bittel et al., Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial, JAMA Netw. Open. 4(2(2021). https://doi.org/10.1001/jamanetworkopen.2021.0369
J. Hackler, R.A. Heller, Q. Sun et al., Relation of Serum Copper Status to Survival in COVID-19, Nutrients. 13(6(2021) 1898. https://doi.org/10.3390/nu13061898
