LATENT AUTOIMMUNE DIABETES IN ADULTS: DIAGNOSIS, TREATMENT AND CLINICAL FEATURES
Keywords:
Type 1 diabetes mellitus, LADA diabetes, beta cells, insulin, sugar.Abstract
Latent autoimmune diabetes in adults (LADA) is a special type of diabetes that combines features of both type 1 and type 2 diabetes. The development and progression of LADA is due to multiple factors, including immunological, genetic and environmental. An autoimmune attack on pancreatic beta cells, leading to a decrease in their function, is the central pathogenetic mechanism. In this case, the presence of specific autoantibodies, such as antibodies to glutamate decarboxylase (GADA), serves as an important diagnostic marker. Genetic factors, particularly variations in HLA genes, also play a significant role, indicating a hereditary predisposition to the condition. In addition, environmental factors such as viral infections and lifestyle changes can act as triggers for the onset of the autoimmune process.
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