THE FUNCTIONS OF SKIN LANGERHANS CELLS IN IMMUNE TOLERANCE AND CANCER IMMUNITY
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Аннотация:
Langerhans cells (LC) are a distinct population of tissue-resident macrophages with dendritic cell (DC) functionality, forming a dense network across the epidermis. Positioned at the skin barrier, LC serve as critical immune sentinels at the interface between the body and the environment. Historically classified as DCs, extensive research has focused on their ability to prime T cell immunity. However, LC possess unique macrophage-like properties, and recent studies reveal their immunoregulatory roles both in steady-state conditions and during specific inflammatory responses. This highlights the influence of the cutaneous microenvironment in shaping LC functionality. This mini-review explores emerging insights into the role of LC in immune tolerance under normal and pathological conditions, including malignant transformation and progression. Additionally, we examine LC functional plasticity in response to microenvironmental cues and the potential relationship between LC heterogeneity and functional diversity. Understanding the molecular mechanisms that enable LC to integrate environmental signals and modulate immune responses is crucial for advancing tumor immunology, vaccine development, and therapies for inflammatory skin disorders.
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