SYSTEMIC LUPUS ERYTHEMATOSUS AND CARDIOVASCULAR PATHOLOGY
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Аннотация:
Systemic lupus erythematosus, sometimes known as SLE, is a type of autoimmune illness that can express itself in a dizzying array of different ways in patients. Atherosclerosis and the conditions that result from it are the leading causes of late mortality in people who have complications from SLE. Traditional risk factors, the presence of specific risk factors, the duration of the course, the use of glucocorticoids (GC), the presence of autoantibodies to double-stranded (native) DNA, and the presence of antiphospholipid antibodies all create conditions that accelerate the development of atherosclerosis in this group of patients. The research that is now available suggests that established risk factors for cardiovascular disease should be revised in order to take into consideration the beneficial effect of antimalarial medications as well as the unfavorable prognostic effect of prolonged use of GC.
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Pisetsky DS. Bossuyt X, Meroni PL ANA as an entry criterion for the classification of SLE. // Autoimmun Rev. 2019 Oct 19:102400. doi: 10.1016/j.autrev.2019.102400
Ruiz-Limon P. Barbarroja N. Perez-Sanchez C, et aL Atherosclerosis and cardiovascular disease in systemic lupus erythematosus: effects of in vivo statin treatment. // Ann Rheum Dis. 2015;74(7):1450-8. doi: 10.1136/annrheum-dis-2013-204351
Tsokos GC, Lo MS, Costa Reis P. Sullivan KE. New insights into the immunopathogenesis of systemic lupus erythematosus. I/ Nat Rev Rheumatol. 2016; 12( 12):716-30. doi: 10.1038/ nrrheum.2016.186
Chang HD, Tokoyoda K. Hoyer B, et aL Pathogenic memory plasma cells in autoimmunity. // Curr Opin Immunol. 2019;61:86-91. doi: 10.1016/j.coi.2019.09.005
Chang HD, Tokoyoda K. Hoyer B, et aL Pathogenic memory plasma cells in autoimmunity. // Curr Opin Immunol. 2019;61:86-91. doi: 10.1016/j.coi.2019.09.005
Little J, Parker B, Lunt M. et aL Glucocorticoid use and factors associated with variability in this use in the systemic lupus international collaborating clinics inception cohort.// Rheumatology. 2018;57:677-87. doi: 10.1093/rheumatology/ kex444
Pisetsky DS. Bossuyt X, Meroni PL ANA as an entry criterion for the classification of SLE. // Autoimmun Rev. 2019 Oct 19:102400. doi: 10.1016/j.autrev.2019.102400