THE IMPORTANCE OF COLCHICINE IN MANAGING SKIN CANCER CELLS

Abstrak

Skin cancer is the most common type of cancer worldwide, affecting millions of people annually. It is divided into two main categories: melanoma and non-melanoma skin cancers (such as basal cell carcinoma and squamous cell carcinoma). The high incidence of skin cancer, along with rising cases due to increased UV exposure, has prompted the need for more effective treatments. At the core of colchicine's anticancer effect is its inhibition of microtubule dynamics, leading to the disruption of mitosis in rapidly dividing cancer cells. Beyond microtubule inhibition, colchicine has also been shown to induce apoptosis through several pathways, including activation of caspases, inhibition of the anti-apoptotic Bcl-2 protein, and regulation of p53. Additionally, colchicine disrupts the tumor vasculature by inhibiting endothelial cell function, thus impairing tumor angiogenesis