DO NONSTEROIDAL ANTI-INFLAMMATORY DRUGS HAVE A PATHOGENETIC EFFECT?
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pathogenetic action, osteoarthritis, ankylosing spondylitis.Abstrak
The information presented in the review can serve as a rationale for more active use of NSAIDs in cases where there are direct indications for their use. It is indicated that it is advisable to move from the tactics of purely symptomatic use of these drugs (“only when pain appears”) to the practice of regular use in a constant daily dose if pain in the joints and/or spine is present most of the time.
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Karateev A.E., Karateev D.E., Luchikhina E.L. et al. Efficacy and safety of high-dose NSAID monotherapy in early arthritis. RMZh 2016;16:24–9.
Greenwald M., Peloso P., Mandel D. et al. Further assessment of the clinically effective dose range of etoricoxib: a randomized, double-blinded, placebo-controlled trial in rheumatoid arthritis. Curr Med Res Opin 2011;27(10):2033–42.
Pincus T. Clinical evidence for osteoarthritis as an inflammatory disease. Curr Rheum Rep 2016;3(6):524–34.
Fernandes J., Martel-Pelletier J., Pelletier J. The role of cytokines in osteoarthritis pathophysiology. Biorheology 2012;39(1–2):237–46.
