THE IMPORTANCE OF COLCHICINE AND ITS THERAPEUTIC APPLICATIONS IN DERMATOLOGY

Abstract

Colchicine has been primarily recognized for its use in gout and familial Mediterranean fever (FMF), but its broader anti-inflammatory and immunomodulatory effects have drawn attention to its potential in dermatology. Dermatological disorders, particularly those involving immune dysregulation and chronic inflammation, have demonstrated responsiveness to colchicine therapy. This thesis will evaluate the mechanisms underlying colchicine’s dermatological applications, summarize its current uses, and discuss future potential as an adjunct or alternative to more traditional treatments.