ENDOMETRIAL RETSEPTIVLIK BUZILIGAN HOLATLARDA TROMBOTSITLARGA BOY PLASMA SAMARADORLIGINI OSHIRISH: ZAMONAVIY REGENERATIV VA IMMUNOMODULYATOR STRETEGIYALAR
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trombotsitlarga boy plazma (TBP), endometrial retseptivlik, immunomodulyatsiya, angiogenez, regeneratsiya, bepushtlik, implantatsiya muvaffaqiyatsizligiAbstrak
Endometrial retseptivlik – bu bachadon shilliq qavatining embrionni qabul qilish va muvaffaqiyatli implantatsiya qilishga tayyor holatidir. Ushbu holatning buzilishi bepushtlikning asosiy sabablaridan biri hisoblanadi, ayniqsa, endometrioz, surunkali endometrit yoki yupqa endometriy fonida kuzatiladi. Retseptivlik buzilganda, hatto sog‘lom va sifatli embrion ham endometriyga yopishmaydi.
Iqtiboslar
Du J., Lu H., Yu X., Lü Z., Mi L., Zhang X.Efficacy and safety of platelet-rich plasma for the treatment of thin endometrium: A protocol for systematic review and meta-analysis.Medicine (Baltimore), 2020; 99(18): e18848. https://doi.org/10.1097/MD.0000000000018848
Obidniak D., Gzgzyan A., Niauri D., et al.Randomized controlled trial evaluating efficacy of autologous platelet-rich plasma therapy for patients with recurrent implantation failure.Human Reproduction, 2023; 38(S1): dead093.
Elnafarawi M.A., Elsherbiny M.F., Tawfik W.M., EIbrahim D.M.The role of platelet-rich plasma (PRP) in recurrent implantation failure (RIF).Benha Journal of Applied Sciences, 2022; 7(2): 127–134.
Lessey B.A., Young S.L.What exactly is endometrial receptivity?Fertility and Sterility, 2019; 111(4): 611–617.
Alawadhi F., Du H., Cakmak H., Taylor H.S.Bone marrow-derived stem cell (BMDSC) transplantation improves fertility in a murine model of Asherman's syndrome.PLoS ONE, 2014; 9(5): e96662.
Yu N., Zhang B., Xu M., et al.Platelet-rich plasma improves endometrial receptivity via regulating uNK cells and inflammatory cytokines in mice.Reproductive Biology and Endocrinology, 2020; 18:28.
Chang Y., Li J., Chen Y., et al.Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during IVF.Int J Clin Exp Med, 2015; 8(1): 1286–1290.
Jang H., Kim H., Lee J.H., Kim J.Molecular signature of PRP-induced regeneration in endometrial tissue.J Assist Reprod Genet, 2021; 38(5): 1061–1070.
Salamonsen L.A., Dimitriadis E., Evans J.Dynamic changes in the endometrial microenvironment during the menstrual cycle.Reproduction, 2016; 152(6): R127–R137.
Wu X., Wang Y., Wei L., Liu L.TGF-β1-induced collagen synthesis in endometrial stromal cells through Smad2/3 and CTGF pathways.J Cell Physiol, 2023; 238(1): 89–97.
