SEPSIS PATOGENEZIDA PATOMORFOLOGIK JARAYONLARI VA KLINIK ASOSLARI
Keywords:
sepsis, septik holat, patomorfologik o‘zgarishlar, disseminatsiyalangan intravaskulyar koagulyatsiya (DIC), nekroz, yallig‘lanish, buyrak yetishmovchiligi, o‘pka shikastlanishi, jigar distrofiyasi, gipoksiya.Abstract
Mazkur maqola sepsis va uning og‘ir shakli bo‘lgan septik holat davrida organizmda yuzaga keladigan patomorfologik o‘zgarishlarni tahlil qilishga bag‘ishlangan. Sepsis — bu organizmning infeksiyaga nisbatan kuchli va nazoratsiz yallig‘lanish javobi bo‘lib, u ko‘pincha hayot uchun xavfli holatlarga olib keladi. Septik holatda ko‘p organ yetishmovchiligi, qon aylanish tizimining buzilishi, shuningdek, to‘qimalarda yallig‘lanish, nekroz va shish holatlari kuzatiladi. Maqolada ayniqsa, qon aylanish tizimi, o‘pka, buyrak, jigar va markaziy nerv tizimi kabi hayotiy muhim organlardagi asosiy patomorfologik o‘zgarishlar keng yoritilgan. Disseminatsiyalangan intravaskulyar koagulyatsiya (DIC) — sepsisda keng tarqalgan va og‘ir kechuvchi holat bo‘lib, kapillyarlarda tromblar shakllanishi bilan birga, gemorragik sindromga olib keladi. Shuningdek, o‘pka to‘qimalarida alveolyar septalarning shishishi, gemorragik infiltratsiya va diffuz alveolyar shikastlanishlar qayd etiladi. Buyraklarda glomerulyar nekroz, jigar to‘qimasida distrofik va nekrotik o‘zgarishlar, markaziy nerv tizimida esa gipoksik-ischemik shikastlanishlar uchraydi. Ushbu morfologik o‘zgarishlar sepsisning klinik belgilari va og‘irligini tushunishda, hamda to‘g‘ri davolash strategiyasini ishlab chiqishda muhim ahamiyatga ega. Maqola sepsisning patomorfologik asoslarini chuqur tahlil qilgan holda, klinik amaliyotda muhim axborot manbasi bo‘la oladi.
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