IMMUNITET. IMMUN TIZIMINING TUZILISHI VA FUNKSIYALARI
Keywords:
immunitet, immun tizimi, tug‘ma immunitet, orttirilgan immunitet, limfotsitlar, antitelolar, immun javob, himoya mexanizmlari.Abstract
Immunitet — bu organizmni tashqi va ichki patogen omillardan himoya qiluvchi murakkab biologik tizimdir. Immun tizimi hujayralar, to‘qimalar va maxsus organlar majmuasidan tashkil topib, ularning uyg‘un faoliyati orqali organizmning genetik barqarorligi hamda salomatligi ta’minlanadi. Immunitetning asosiy vazifalari patogen mikroorganizmlarni aniqlash va neytrallash, o‘lik yoki shikastlangan hujayralarni yo‘qotish, shuningdek, organizmning o‘z to‘qimalariga nisbatan tolerantlikni saqlashdan iborat. Maqolada immun tizimining tuzilishi, hujayraviy va gumoral bo‘linmalari, tug‘ma va orttirilgan immunitetning xususiyatlari hamda ularning klinik ahamiyati ilmiy asosda keng yoritiladi.
References
Abbas, A. K., Lichtman, A. H., & Pillai, S. (2021). Cellular and Molecular Immunology. 10th Edition. Elsevier.
Murphy, K., Weaver, C. (2016). Janeway’s Immunobiology. 9th Edition. Garland Science.
Male, D., Brostoff, J., Roth, D., & Roitt, I. (2013). Immunology. 8th Edition. Elsevier Health Sciences.
Chaplin, D. D. (2010). Overview of the Immune Response. Journal of Allergy and Clinical Immunology, 125(2), S3–S23.
Parkin, J., & Cohen, B. (2001). An overview of the immune system. The Lancet, 357(9270), 1777–1789.
Alberts, B., Johnson, A., Lewis, J., et al. (2015). Molecular Biology of the Cell. 6th Edition. Garland Science.
Iwasaki, A., & Medzhitov, R. (2015). Control of adaptive immunity by the innate immune system. Nature Immunology, 16(4), 343–353.
Chaplin, D. D. (2006). Cytokines in the immune response. Nature Immunology, 6(5), 367–374.
Kumar, V., Abbas, A. K., & Aster, J. C. (2020). Robbins and Cotran Pathologic Basis of Disease. 10th Edition. Elsevier.
World Health Organization (2022). Immunization, Vaccines and Biologicals. WHO Official Publications.
