THE EFFECTS OF PIPER NIGRUM (BLACK PEPPER) EXTRACT ON THYMOCYTE CELLS
Abstract
Black pepper (Piper nigrum) has been extensively used in the food industry as a spice and in traditional medicine to improve digestion and appetite. It is rich in flavonoids, polyphenols, alkaloids, and tannins. Recent studies have demonstrated its antioxidant properties, anti-aging effects, and natural antibiotic characteristics. However, the mechanisms by which black pepper extract affects cellular structures, specifically membranes, remain inadequately studied. This study investigates the effects of black pepper extract on the membrane regulatory processes of rat thymocyte cells under hypoosmotic stress conditions.
References
Haslam E. Plant Polyphenols Vegetable Tannins Revisited Chemistry and Pharmacology of Natural Products. // Cambridge University Press, Cambridge, 1989, p. 165.
Hempling H.G., Thompson S., Dupre A. Osmotic properties of human lymphocytes. // J. Cell Physiol., 1977, Vol.93, P.293-302.
Holevinsky K.O., Jow F. and Nelson D.J. Elevation in intracellular calcium activates both chloride and proton currents in human macrophages. // J. Membr. Biol., 1994, 140, 13-30.
Imomov O.N. Ozbekistonning foydali osimliklari. // Oquv-uslubiy majmua, Namangan, 2021.
Ikejima K., Qu W., Stachlewitz R.F. and Thurman R.G. Kupffer cells contain a glycine-gated chloride channel. // Am. J. Physiol., 1997, 272, G1581-G1586.
Inoue T., Jackson E.K. Strong antiproliferative effects of baicalein in cultured rat hepatic stellate cells. // European Journal of Pharmacology, 1999, 378, 129135.
Islam M.R., Uramoto H., Okada T., Sabirov R.Z. and Okada Y. Maxianion channel and pannexin 1 hemichannel constitute separate pathways for swelling-induced ATP release in murine L929 fibrosarcoma cells. // Am. J. Physiol. Cell Physiol., 2012, 303: C924-C935.
Jia M., Ren D., Nie Y., Yang X. Beneficial effects of apple peel polyphenols on vascular endothelial dysfunction and liver injury in high choline-fed mice. // Food Funct., 2017, Vol.8, №3, P. 1282-1292.
Kandaswami C., Middleton E. Free radical scavenging and antioxidant activity of plant flavonoids. // Advances in Experimental Medicine and Biology, 1994, 366, 351356.
Kanai N., Lu R., Satriano J.A., Bao Y., Wolkoff A.W., Schuster V.L. Identification and characterization of a prostaglandin transporter. // Science, 1995, 268: 866-869.
Kappler J.W., Roehm N., Marrack P. T cell tolerance by clonal elimination in the thymus. // Cell, 1987, Vol.49, P.273-280.
Khanbabaee K., Van Ree T. Tannins: Classification and definition. // Nat. Prod. Rep., 2001, 18: 641-649.
K.Narendra Babu, R. Hemalatha, B. Danesh Kumar. Phytochemicals, polyphenols, prebiotic effect of Osimum sanctum, Zingiber officinale, Piper nigrum extracts. // Journal of Herbal Medicine, September 2018, 42-51.
Krasilnikov O.V., Sabirov R.Z., and Okada Y. ATP hydrolysis-dependent asymmetry of the conformation of CFTR channel pore. // J. Physiol. Sci., 2011, 61: 267-278.
Musayeva, S. I. (2024). ADVANTAGES AND DISADVANTAGES OF INTERACTIVE METHODS INTRODUCING THE СLT (СOMMUNIСATIVE LANGUAGE TEACHING) APPROACH. World Scientific Research Journal, 32(1), 217-219.
Kurbannazarova R.S., Tashmukhamedov B.A., Sabirov R.Z. Osmotic water permeability and regulatory volume decrease of rat thymocytes. // Gen. Physiol. Biophys., 2003, Vol.22, P.221-232.
