INDIVIDUALIZED LASER-PHOTODYNAMIC THERAPY IN THE TREATMENT OF POST-BURN SCARS
Abstrak
Post-burn scars remain one of the most difficult challenges in reconstructive and aesthetic dermatology. They often lead to physical discomfort, psychological distress, and social adaptation difficulties, especially when localized on visible parts of the body. Standard treatment methods may not always be effective due to the individual characteristics of scar tissue formation, healing dynamics, and skin type. An individualized approach using combined laser and photodynamic therapy (PDT) presents a promising alternative. This dual-modality strategy enhances treatment efficiency through synergistic effects of laser ablation and cellular-level photochemical reactions induced by photosensitizers. Such an approach aims to optimize treatment outcomes and minimize side effects.
Iqtiboslar
Ahima R.S., Flier J.S. Adipose tissue as an endocrine organ. Trends in Endocrinology & Metabolism. 2000;11(8):327–332.
Kershaw E.E., Flier J.S. Adipose tissue as an endocrine organ. Journal of Clinical Endocrinology & Metabolism. 2004;89(6):2548–2556.
Ouchi N., Parker J.L., Lugus J.J., Walsh K. Adipokines in inflammation and metabolic disease. Nature Reviews Immunology. 2011;11(2):85–97.
Tilg H., Moschen A.R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nature Reviews Immunology. 2006;6(10):772–783.
Steppan C.M., Lazar M.A. The current biology of resistin. Journal of Internal Medicine. 2004;255(4):439–447.
Fasshauer M., Blüher M. Adipokines in health and disease. Trends in Pharmacological Sciences. 2015;36(7):461–470.
Turer A.T., Scherer P.E. Adiponectin: mechanistic insights and clinical implications. Diabetologia. 2012;55(9):2319–2326.
