THE EFFECTS OF 14-BENZOYLKARAKOLINE ON CONTRACTIVE ACTIVITY OF RAT AORTA SMOOTH MUSCLE CELLS
Keywords:
smooth muscles, sarkoplazmic reticulum, aorta, phenylephrine, Ca2 channel, 14-benzoylkarakoline.Abstract
It was investigated how 14-benzoylkarakoline affected the rat aortic smooth muscle cells' ability to contract. According to the results, rat aorta preparations that had been constricted by the beta-adrenergic receptor agonist phenylephrine are successfully relaxed by 14-O-BK. It can be deduced that the relaxant effect of the studied alkaloid is caused by the suppression of the transport of Ca2+ ions at the SR level in light of the fact that the contractions induced by this antagonist are primarily caused by the activation of the release of Ca2+ ions from the SR through IP3R.
References
Roth G.A., Johnson С., Abajobir A., et al. Global, regional and national burden of cardiovascular diseases for 10 causes, 1990 to 2015. // J. Am. Coll. Cardiol. – 2017. – V.70. – P.1-25.
Wright P., Thomas M. Pathophysiology and management of heart failure // Clinical Pharmacist. – 2018. – V.10 (12). – P.261-269.
Djakhangirov F.N., et al., Diterpenoid alkaloids as a new class of antiarrhythmic agents. Structure–activity relationship. Chem. Nat. Compd.1997, 33, 254-269. 262-263.
Mirzayeva Yu.T.et al., Characteristic of the vaszorelaxant action of the talatizamine alkaloid and its derivatives // Journal of Pharmaceutics and Pharmacology Research. 2021, P. 1-5. 16192 Coastal Highway, Lewes, USA.
