STUDY OF THE ACUTE TOXICITY OF “SILA KREMNIYA NANOKREMNIY”
Keywords:
acute toxicity, silicon nanoparticles, microelements, experimental group, intact group.Abstract
This study presents the results of an acute toxicity assessment of the product “Sila Kremniya Nanokremniy”, based on silicon nanoparticles supplemented with microelements. The research was conducted on laboratory mice and rats under standard conditions. The findings revealed that the tested compound did not produce any signs of acute toxicity even at high doses (up to 5000 mg/kg), indicating its safety for further pharmacological research.
References
Sokolov S.Ya. Phytotherapy and Phytopharmacology: A Guide for Physicians. Moscow: Medical Information Agency, 2000.
Gus’kova T.A. Toxicology of Medicinal Products. Moscow, 2008. pp. 27–30.
Mironov A.I. (Ed.) Guidelines for Conducting Preclinical Studies of Drugs. Moscow: Grif and K, 2012.
Nazarenko G.I., Kishkun A.A. Clinical Evaluation of Laboratory Test Results. Moscow: Medicine, 2005.
Khabriev R.U. (Ed.) Manual on Experimental (Preclinical) Study of New Pharmacological Substances. 2nd ed. Moscow: Medicine, 2005. pp. 763–774.
Stefanov A.V. Preclinical Research of Medicines. Kiev, 2002. p. 91.
United Nations. Globally Harmonized System of Classification and Labelling of Chemicals (GHS), 9th Edition. UNECE, 2021.
