METHODS OF STUDYING THE INFLUENCE OF ENVIRONMENTAL FACTORS ON HEREDITARY GENETIC DISEASES
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Irsiy genetik kasalliklar, atrof-muhit omillari, gen va atrof-muhitning o'zaro ta'siri, GWAS, epigenetika, epidemiologiya, egizaklarni o'rganish, genetik moyillik.Abstrak
Irsiy genetik kasalliklar irsiy mutatsiyalar tufayli yuzaga keladi, ammo atrof-muhit omillari ularning paydo bo'lishi, zo'ravonligi va rivojlanishiga sezilarli ta'sir ko'rsatishi mumkin. Genetika va atrof-muhitga ta'sir qilish o'rtasidagi o'zaro ta'sirni tushunish profilaktika strategiyalari va shaxsiylashtirilgan davolanishni ishlab chiqish uchun juda muhimdir. Ushbu maqolada genetik kasalliklarga atrof-muhit omillarining ta'sirini o'rganish uchun ishlatiladigan turli usullar, jumladan epidemiologik tadqiqotlar, egizak tadqiqotlar, genom bo'yicha assotsiatsiyalar (GWAS), epigenetik tadqiqotlar va hayvonlar modellari muhokama qilinadi. Har bir usul genlar va atrof-muhit o'rtasidagi o'zaro ta'sirlar haqida noyob ma'lumot beradi, bu kasallik mexanizmlarini kengroq tushunishga yordam beradi.
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