ANAL INTRAEPITHELIAL NEOPLASIA IN WOMEN WITH HUMAN PAPILLOMAVIRUS-ASSOCIATED LESIONS OF THE CERVIX, VULVA, AND VAGINA
Keywords:
Anal intraepithelial neoplasia (AIN); human papillomavirus (HPV); cervical intraepithelial neoplasia (CIN); field cancerization; multifocal lesions; screening; early diagnosis; HSIL; anogenital carcinogenesis.Abstract
The present study addresses the clinically significant issue of anal intraepithelial neoplasia (AIN) in women with previously diagnosed human papillomavirus (HPV)-associated lesions of the cervix, vulva, and vagina. Particular emphasis is placed on the role of the anal canal as a potential viral reservoir, facilitating persistent HPV infection. The concept of “field cancerization” is considered as a theoretical framework explaining the high prevalence of multifocal lesions within the anogenital epithelium.
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