RESEARCH ON THE DEVELOPMENT OF CAPSULE COMPOSITION AND TECHNOLOGY BASED ON DRY EXTRACT FROM WALNUT LEAVES
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Dry extract, Juglans regia L, capsules, biologically active additive, excipients, pharmaco-technological indicators, technology.Abstrak
This article presents the results of research aimed at selecting the optimal composition and developing the technology of capsules based on dry extract obtained from walnut leaves. For this purpose, encapsulated masses were prepared using widely used fillers and moisturizing agents, and their pharmaco-technological indicators were evaluated. As a result, it was established that the most optimal filler for a biologically active additive in the form of a capsule containing a dry extract of walnuts as an active substance is a 1:1 ratio of microcrystalline cellulose and aerosil, a moisturizing agent is a 10% starch solution. Based on this composition, the technology of capsules based on dry walnut extract was developed.
Iqtiboslar
Abu Ali ibn Sina. Canon of Medical Science.- Publishing House: Amrita.-2007.- 5928p.
Berzegova A.A. Chemical composition of walnut fruits // New technologies. - 2007.- No 4. - P. 42-43.
Daironas J.V., Kuleshova S.A., Pshukova I.V. Phytochemical study of walnut leaves as a source of antioxidant agent // Chemistry of plant raw materials.- 2010.- No4.- P. 95-98.
Chebyshev N.V., Martemyanova L.O., Strelyaeva A.V. et al. Study of external signs, microscopy and chemical composition of walnut septa //Sechenov Bulletin.- 2018.-No 4 (34).-P.60-69. DOI: 10.26442/22187332.2018.4.60-69
Cosmulescu S., Trandafir I., Nour V. Seasonal variation of the main individual phenolics and juglone in walnut (Juglans regia) leaves // Pharm. Biol.- 2014.-Vol.52 (5).-P. 575–80.
Umurzakov E.U., Pulatov O.A., Abdullayev K.T. Walnut (Juglans regia L.). Monograph. - Samarkand. 2023. - 224 p.
Zimenkina N.I. Comparative pharmacognostic study of some representatives of the walnut genus (Juglans regia L.). - Diss. for the degree of Candidate of Pharmaceutical Sciences.- Samara 2022.- P.10-13.
Gorokhova S.V. Useful Properties of Representatives of the Juglans L. Genus //Bulletin of IrGSHA. -2011.-No 44 (4).-P.34-40.
Yenikeeva R.A. Research on the pharmacognitive study and standardization of raw materials and preparations of walnut (Juglans regia L.): abstract of diss. cand. pharmac. sciences. M., 2008. -21 p.
Poddubnaya I.S., Maksimkina E.A., Bagirova V.L., Sokolova V., Gorelova S. Osteoporosis: problems of treatment and assortment of LS //Remedium.-2004.-No3.-P.21-27.
Sultanova M.S., Khodzhaeva M.A. Standardization of the bark of walnut fruits // Materials of the scientific and practical conference "Integration of education, science and production in pharmacy."- Tashkent, 2011.- P.300-301.
Khalmatov Kh.Kh., Khodzhaeva M.A. Isolation and identification of phenolic carboxylic acids from walnut leaves // Pharmaceutical Journal.- 2007. - No 1. - P. 18-21.
Khodjaeva M.A., Fayzullaeva Z.R., Muhamedova M.Sh. Phytoncitic properties of walnut leaf extract // Asian journal of pharmaceutical and biological research.- 2021.- Vol.10-№1.- P.7-12
State Pharmacopoeia of the Republic of Uzbekistan. First Edition.-Chapter 2. Tashkent [Electronic resource].
State Pharmacopoeia of the Russian Federation, XIV ed., Moscow (2018); [Electronic resource], URL: http://femb.ru/feml.
