STUDY OF ZINC OXIDE NANOPARTICLE-BASED SUPPOSITORIES: IN VITRO ANTIMICROBIAL ACTIVITY AND APPLICATION PROSPECTS
Keywords:
Scutellaria Iscanderi L., zinc oxide nanoparticles (ZnO-NPs), antimicrobial activity, in vitro, suppositories, infectious-inflammatory diseases, herbal extract, local treatment.Abstract
This study focuses on the development and comprehensive evaluation of suppository dosage forms containing zinc oxide nanoparticles (ZnO-NPs) to assess their in vitro antimicrobial activity. Given the growing interest in the application of nanomaterials in the pharmaceutical industry, especially for localized drug delivery, the incorporation of ZnO-NPs into suppositories represents a promising approach for treating infectious and inflammatory gynecological conditions. The developed suppositories demonstrated uniform nanoparticle distribution, ensuring formulation stability, dosage consistency, and controlled release of the active ingredient.
References
Andrade G.R.S. et al. Development of rectal mucoadhesive formulations containing zinc oxide nanoparticles: Physicochemical, mucoadhesive and antimicrobial evaluation. J Pharm Sci Res, 2020;12(1):10–17.
Dimapilis E.A.S. et al. Zinc oxide nanoparticles: A review of green synthesis, antimicrobial activity and cytotoxicity. Materials Science for Energy Technologies, 2018;1(3): 106–113. DOI: 10.1016/j.mset.2018.06.002
Ghaffari H. et al. Green synthesized zinc oxide nanoparticles with antibacterial and antifungal activities. Materials Science & Engineering C, 2020;113:110975. DOI: 10.1016/j.msec.2020.110975
Rasmussen J.W. et al. Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications. Expert Opin Drug Deliv. 2010;7(9):1063–1077. DOI: 10.1517/17425247.2010.502560
Sahibzada M.U.K. et al. ZnO nanoparticles as drug delivery systems: A review of current status and future prospects. Colloids and Surfaces B: Biointerfaces, 2022;213:112384. DOI: 10.1016/j.colsurfb.2022.112384
Sirelkhatim A. et al. Review on zinc oxide nanoparticles: Antibacterial activity and toxicity mechanism. Nano-Micro Letters, 2015;7(3):219–242. DOI: 10.1007/s40820-015-0040-x
Tian X. et al. Antibacterial mechanism of ZnO nanoparticles: Induction of ROS generation, membrane damage, and autophagy. Frontiers in Microbiology, 2023;14:1295593. DOI: 10.3389/fmicb.2023.1295593
Wong R. et al. Zinc oxide nanoparticles suppress inflammation and promote tissue repair in inflammatory bowel disease models. Nanomedicine: NBM, 2021;36:102433. DOI: 10.1016/j.nano.2021.102433
