DIABETES MELLITUS IN NEWBORNS
Article Sidebar
Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.
Main Article Content
Аннотация:
This article provides a comprehensive exploration of diabetes mellitus in newborns, delving into its causes, diagnostic methods, and treatment options. By highlighting the genetic and autoimmune factors contributing to neonatal diabetes, it offers valuable insights for medical professionals. The discussion on clinical symptoms and genetic testing aims to enhance early detection, enabling prompt intervention. Emphasizing the significance of insulin therapy and long-term management, the article addresses the complex nature of diabetes in newborns. Additionally, it underscores the potential impact on developmental aspects, advocating for proactive measures and holistic care. Overall, the article serves as an informative guide for healthcare professionals and families navigating the intricacies of diabetes mellitus in the neonatal context.
Article Details
Как цитировать:
Библиографические ссылки:
Iafusco D, Massa O, Pasquino B, Colombo C, Iughetti L, Bizzarri C, et al. Minimal incidence of neonatal/infancy onset diabetes in Italy is 1:90,000 live births. Acta Diabetol. (2012) 49:405–8. doi: 10.1007/s00592-011-0331-8
Kanakatti Shankar R, Pihoker C, Dolan LM, Standiford D, Badaru A, Dabelea D, et al. Permanent neonatal diabetes mellitus: prevalence and genetic diagnosis in the SEARCH for diabetes in Youth Study. Pediatr Diabetes.(2013)14:174–80. doi: 10.1111/pedi.12003
Polak M, Cave H. Neonatal diabetes mellitus: a disease linked to multiple mechanisms. Orphanet J Rare Dis. (2007) 2:12. doi: 10.1186/1750-1172-2-12
Busiah K, Drunat S, Vaivre-Douret L, Bonnefond A, Simon A, Flechtner I, et al. Neuropsychological dysfunction and neurodevelopmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study. Lancet Diabetes Endocrinol. (2013) 1:199–207.doi: 10.1016/S2213-8587(13)70059-7
Huopio H, Miettinen PJ, Ilonen J, Nykänen P, Veijola R, Keskinen P, et al.Clinical, genetic, and biochemical characteristics of early-onset diabetes in the Finnish population. J Clin Endocrinol Metab. (2016) 101:3018–26. doi: 10.1210/jc.2015-4296
Temple IK, Gardner RJ, Robinson DO, Kibirige MS, Ferguson AW, Baum JD, et al. Further evidence for an imprinted gene for neonatal diabetes localised to chromosome 6q22-q23. Hum Mol Genet. (1996) 5:1117–21. doi: 10.1093/hmg/5.8.1117
Cave H, Polak M, Drunat S, Denamur E, Czernichow P. Refinement of the 6q chromosomal region implicated in transient neonatal diabetes. Diabetes.(2000) 49:108–13. doi: 10.2337/diabetes.49.1.108
Gardner RJ, Mackay DJ, Mungall AJ, Polychronakos C, Siebert R, Shield JP, et al. An imprinted locus associated with transient neonatal diabetes mellitus. Hum Mol Genet. (2000) 9:589–96. doi: 10.1093/hmg/9.4.589
Arima T, Drewell RA, Arney KL, Inoue J, Makita Y, Hata A, et al. A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus. Hum Mol Genet. (2001) 10:1475–83.doi: 10.1093/hmg/10.14.1475
Ma D, Shield JP, Dean W, Leclerc I, Knauf C, Burcelin RR, et al. Impaired glucose homeostasis in transgenic mice expressing the human transientneonatal diabetes mellitus locus, TNDM. J Clin Invest. (2004) 114:339–48. doi: 10.1172/JCI200419876
Docherty LE, Kabwama S, Lehmann A, Hawke E, Harrison L, Flanagan SE,et al. Clinical presentation of 6q24 transient neonatal diabetes mellitus (6q24TNDM) and genotype-phenotype correlation in an international cohort of patients. Diabetologia. (2013) 56:758–62. doi: 10.1007/s00125-013-2832-1
Mackay DJ, Callaway JL, Marks SM, White HE, Acerini CL, Boonen SE, et al.
Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57. Nat Genet. (2008) 40:949–51. doi: 10.1038/ng.187
Clement JP, Kunjilwar K, Gonzalez G, Schwanstecher M, Panten U, Aguilar- Bryan L, et al. Association and stoichiometry of KATP.