BIOCHEMICAL MARKERS OF OXIDATIVE STRESS IN CHILDREN WITH AFFECTIVE-RESPIRATORY PAROXYSM
Keywords:
Affective-Respiratory Paroxysm, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GP), oxidative stress.Abstract
This study aimed to assess the level of oxidative stress in children with Affective-Respiratory Paroxysm (ARP). The results showed that the ARP group had higher levels of malondialdehyde (MDA) and lower activities of superoxide dismutase (SOD) and glutathione peroxidase (GP). This indicates that oxidative stress may play an important role in the pathogenesis of ARP. Compared to the scientific literature, these results confirm the weakening of the antioxidant defense system in conditions associated with ARP. Thus, future research should focus on studying therapeutic approaches aimed at reducing oxidative stress.
References
Ghezzi, P. (2020). Oxidative stress and inflammation: Mechanisms and relevance to disease. Free Radical Biology and Medicine, 157, 4-6. https://doi.org/10.1016/j.freeradbiomed.2020.05.010
Halliwell, B., & Gutteridge, J. M. C. (2019). Free radicals in biology and medicine (5th ed.). Oxford University Press.
Kane, M., Roberts, L., & Thompson, J. (2021). Catalase activity in pediatric neurological disorders: A comparative study. Journal of Pediatric Biochemistry, 14(3), 112-119. https://doi.org/10.1002/jpbi.2021.003
Tain, Y. L., Hsu, C. N., & Chan, J. Y. H. (2022). Oxidative stress in pediatric diseases: New insights and therapeutic strategies. International Journal of Molecular Sciences, 23(5), 2451. https://doi.org/10.3390/ijms23052451
