HEMORRHAGIC CYSTITIS IN PATIENTS AFTER ALLOGENEIC BONE MARROW CELL TRANSPLANTATION
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Abstract:
Hemorrhagic cystitis (HC) is a life-threatening complication in patients who have undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT). Studies of the potential etiology of HC and its outcomes are limited to isolated publications, and a standard therapeutic approach to the treatment of HC has not been developed. Despite the use of new drugs, including allogeneic hematopoietic stem cell transplantation (allo-HSCT), protease inhibitors, and new immunomodulators, human cells, as well as monoclonal antibodies, remain a key component of the treatment algorithm for patients with acute leukemia (ALL), who are considered potential candidates for high-dose therapy due to their somatic status [1–3].
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