CLINICAL, HORMONAL, AND PERINATAL OUTCOMES OF COVID-19 IN THIRD-TRIMESTER PREGNANCY: A RETROSPECTIVE ANALYSIS
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Abstract:
This retrospective study aimed to evaluate the clinical course of COVID-19, alterations in maternal steroid hormone levels, and associated perinatal outcomes in pregnant women infected with SARS-CoV-2 during the third trimester. A total of 100 pregnant women were enrolled, including 100 patients with confirmed COVID-19. The findings demonstrated that even mild forms of the infection were associated with increased maternal risks, whereas severe disease was accompanied by a significant decline in estradiol and progesterone concentrations, indicating impaired uteroplacental blood flow. The most frequent obstetric complications included iron-deficiency anemia (37.5%), threatened preterm birth (27.5%), and a high cesarean section rate (47.5%). Neonatal resuscitation was required in 7.5% of cases. Overall, the study confirms that COVID-19 substantially increases the risk of adverse clinical and perinatal outcomes in late pregnancy.
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