EARLY DIAGNOSIS OF FOLLICULOGENESIS DISORDERS BASED ON OXIDATIVE STRESS BIOMARKERS: A CLINICAL–BIOCHEMICAL APPROACH
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Abstract:
This study aimed to evaluate the relationship between oxidative stress biomarkers — ROS, MDA and TAC — and ovarian function parameters, as well as to determine their diagnostic value in the early detection of folliculogenesis disorders. A prospective study conducted in 2024–2025 included 90 women divided into three groups based on oxidative stress levels. Women with high oxidative stress demonstrated significantly reduced AMH levels, elevated FSH and nearly a threefold decrease in AFC. ROS and MDA levels were markedly elevated, while TAC was significantly reduced. Correlation analysis revealed a strong negative association between ROS and AMH, a moderate negative association with AFC, and a positive association with FSH. ROC analysis demonstrated an AUC of 0.84 for ROS > 30%, whereas the combined marker AMH < 1.1 ng/mL + ROS > 32% achieved an AUC of 0.91. Overall, oxidative stress biomarkers were shown to have high predictive value for early identification of folliculogenesis impairment and declining ovarian reserve.
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