FOLIC ACID DEFICIENCY AND ITS SIGNIFICANCE: PATHOGENESIS, CLINICAL OUTCOMES, RISK FACTORS, EPIDEMIOLOGICAL SITUATION AND PREVENTIVE STRATEGIES

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Issue: Vol. 5 No. 11 Part 2 : Eurasian Journal of Medical and Natural Sciences
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Toshkent tibbiyot universiteti Termiz filiali Pediatriya fakulteti Fundamental tibbiyot 201- b guruh
xojamuratovamehribon2@gmail.com
Tibbiy va biologik kimyo kafedrasi assistenti Toshkent Tibbiyot Akademiyasi Termiz filiali
info@in-academy.uz

Abstract:

This article provides an in-depth analysis of the biochemical and physiological roles of folic acid (vitamin B9), focusing on DNA and RNA synthesis, cell division, methylation reactions, hematopoiesis, and embryonic development. The pathophysiological mechanisms of folate deficiency, global and regional epidemiological indicators, and clinical outcomes—including megaloblastic anemia, neural tube defects, cardiovascular diseases, depression, and cognitive impairment—are examined based on evidence-based data. Risk groups, folate requirements during pregnancy, the consequences of micronutrient deficiency, and the effectiveness of fortification programs are evaluated. The findings confirm that adequate folic acid intake is a crucial determinant for perinatal health, prevention of neonatal disabilities, and reduction of hematological and cardiometabolic risks.

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Xujamuratova, M., & Ximmatova , Y. (2025). FOLIC ACID DEFICIENCY AND ITS SIGNIFICANCE: PATHOGENESIS, CLINICAL OUTCOMES, RISK FACTORS, EPIDEMIOLOGICAL SITUATION AND PREVENTIVE STRATEGIES. Eurasian Journal of Medical and Natural Sciences, 5(11 Part 2), 51–57. Retrieved from https://in-academy.uz/index.php/EJMNS/article/view/67224

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