INFLUENCE OF PESTICIDES ON HEPATIC CELLS: MECHANISMS AND HEALTH IMPLICATIONS
Article Sidebar
This work is licensed under a Creative Commons Attribution 4.0 International License.
Main Article Content
Abstract:
Pesticides – chemical substances used in agriculture to control pests and improve crop yields have been linked to adverse effects on human health when exposure is chronic or acute. The liver, as the principal organ responsible for xenobiotic metabolism and detoxification, is especially susceptible. Hepatic cells including hepatocytes are primary targets of pesticide-induced toxicity. This article reviews the molecular and cellular effects of pesticides on liver tissue, highlighting key mechanisms and health outcomes with scientific references.
Article Details
How to Cite:
References:
Marjanović A. M. et al., Redox imbalance caused by pesticides: a review of OPENTOX-related research, Arch Ind Hyg Toxicol. (2018).
Wang R., Yang X. et al., Synergistic effects of pesticide mixtures on oxidative stress, apoptosis and necrosis in HepG2 cells, Ecotoxicology and Environmental Safety, 2023.
Yang Y. et al., Natural pyrethrin-induced oxidative damage in human liver cells through the Keap1/Nrf-2 pathway, Toxics, 2024.
Fenitrothion + lambda-cyhalothrin mixture study on rat liver enzymes, PubMed, 2011.
Hussain S. et al., Hepatoprotective effect of curcumin nano-lipid carrier against cypermethrin toxicity, Molecules, 2023.
Tuychieva D. et al., Influence of pesticides on hepatic morphological and biochemical parameters, BIO Web of Conferences, 2024.