ON THE ISSUE OF PHYSIOLOGY OF THE BLOOD SYSTEM
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Abstract:
The article emphasizes that accurate physiological interpretation of blood parameters requires a shift from a "slice of values" to modeling time dynamics and contextual normalization for individual conditions. It is concluded that the most promising approach is the integration of cellular, biochemical, and rheological data into unified functional indices, enabling the comparison of adaptation profiles and the identification of early dysregulation before clinical manifestations.
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Turner J.R. Intestinal mucosal barrier function in health and disease // Nature Reviews Immunology. – 2009. – Vol. 9. – P. 799–809.
Günzel D., Yu A.S.L. Claudins and the modulation of tight junction permeability // Physiological Reviews. – 2013. – Vol. 93. – P. 525–569.
Drozdowski L.A., Thomson A.B.R. Intestinal sugar transport // World Journal of Gastroenterology. – 2006. – Vol. 12(11). – P. 1657–1670.
Camilleri M. Leaky gut: mechanisms, measurement and clinical implications // Gut. – 2019. – Vol. 68. – P. 1516–1526.
Bischoff S.C. et al. Intestinal permeability – a new target for disease prevention and therapy // BMC Gastroenterology. – 2014. – Vol. 14. – P. 189.
Vancamelbeke M., Vermeire S. The intestinal barrier: a fundamental role in health and disease // Expert Review of Gastroenterology & Hepatology. – 2017. – Vol. 11(9). – P. 821–834.
Keely S., Talley N.J., Hansbro P.M. Pulmonary–intestinal cross-talk in mucosal inflammatory disease // Mucosal Immunology. – 2012. – Vol. 5. – P. 7–18.
Agus A., Planchais J., Sokol H. Gut microbiota regulation of tryptophan metabolism in health and disease // Cell Host & Microbe. – 2018. – Vol. 23. – P. 716–724.
Peterson L.W., Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis // Nature Reviews Immunology. – 2014. – Vol. 14. – P. 141–153.
Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation // Physiological Reviews. – 2011. – Vol. 91. – P. 151–175.

