MORPHOLOGICAL FEATURES OF INTESTINAL LYMPH FOLLICLES UNDER CONDITIONS OF EXPERIMENTAL DEHYDRATION
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Abstract:
Disturbances in water balance in the body significantly affect numerous physiological processes. Under conditions of dehydration, hemoconcentration, microcirculatory disorders, and tissue hypoxia may negatively influence various components of the immune system, particularly gut-associated lymphoid tissues. The intestinal lymphatic system, including Peyer’s patches and solitary lymphoid follicles, plays an important role in the formation of local immune responses. The aim of this study was to determine the morphological and morphometric changes in the lymphoid follicles of the small intestine under conditions of experimental dehydration. The study was carried out under laboratory conditions using white rats as an experimental model. In the experimental group of animals, dehydration was induced by restricting fluid intake. The obtained intestinal tissues were examined using histological methods followed by detailed morphological analysis. The results of the study demonstrated that dehydration leads to a decrease in the number of lymphocytes within intestinal lymphoid follicles, alterations in cellular composition, and morphological restructuring of the lymphatic capillary network. In addition, dystrophic and destructive processes in the intestinal wall layers were observed to intensify. The obtained results contribute to a better understanding of structural changes in the intestinal immune system under dehydration conditions and help clarify the pathomorphological mechanisms associated with water deficiency in the organism
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Brandtzaeg P. Function of mucosa-associated lymphoid tissue in antibody formation. Immunological Investigations. 2010;39(4–5):303–355.
Mowat A.M., Agace W.W. Regional specialization within the intestinal immune system. Nature Reviews Immunology. 2014;14(10):667–685.
Kato S., Tsuruta T., Akiba Y. Intestinal immune responses and organization of lymphoid tissue in the gut. Journal of Gastroenterology. 2016;51(5):473–484.
Guseinov A.G., Aliev R.M., Magomedov M.A. Morphological changes of the intestine under various stress factors. Morfologiya. 2008;133(4):45–49.
Abdullaev H.A., Rasulov H.A. Morfologiya limfaticheskoy sistemy kishechnika. – Tashkent: Meditsina, 2015. – 220 p.
Pabst O. New concepts in the generation and functions of IgA. Nature Reviews Immunology. 2012;12(12):821–832.
Macpherson A.J., McCoy K.D., Johansen F.E., Brandtzaeg P. The immune geography of IgA induction and function. Mucosal Immunology. 2008;1(1):11–22.
Neutra M.R., Kozlowski P.A. Mucosal vaccines: the promise and the challenge. Nature Reviews Immunology. 2006;6(2):148–158.
Ramasamy R., Subramanian S. Structural organization of Peyer’s patches and their role in mucosal immunity. International Journal of Morphology. 2018;36(3):1001–1007.
Santos J., Yang P.C., Söderholm J.D., Benjamin M., Perdue M.H. Role of mast cells in intestinal immune responses. Gut. 2001;48(4):546–552.