DETERMINATION OF THE INFLUENCE OF TECHNOLOGICAL FACTORS ON THE RELEASE OF FERROUS FUMARATE FROM AFEROL TABLETS USING MATHEMATICAL MODELING

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Issue: Vol. 6 No. 3 : Eurasian Journal of Medical and Natural Sciences
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Ташкентский фармацевтический институт, Ташкент, Узбекистан
holida_222@mail.ru
Ташкентский фармацевтический институт, Ташкент, Узбекистан
nargiza.samo@yandex.ru
Фармацевтическое предприятие ООО «SAMO», Ташкент, Узбекистан
shurangiz.kasimova@mail.ru

Abstract:

The aim of this study was to develop and simulate a Weibull mathematical model based on experimentally derived dissolution profiles of Aferol tablets (active ingredient: ferrous fumarate 210 mg, equivalent to 65 mg Fe²⁺) in order to quantitatively assess the influence of key technological factors on the kinetics of active substance release. Particular emphasis was placed on the effects of compression pressure (100–300 MPa), tablet geometrical characteristics (diameter 8–10 mm, surface area), composition of excipients (magnesium stearate 0.5–2 %, corn starch, colloidal silicon dioxide, talc, polyvinylpyrrolidone), particle size distribution of the granulate, and residual granulate moisture content (1.25–3 %).

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Юнусова, Х. ., Илхамова, Н. ., & Касимова , Ш. . (2026). DETERMINATION OF THE INFLUENCE OF TECHNOLOGICAL FACTORS ON THE RELEASE OF FERROUS FUMARATE FROM AFEROL TABLETS USING MATHEMATICAL MODELING. Eurasian Journal of Medical and Natural Sciences, 6(3), 86–97. Retrieved from https://in-academy.uz/index.php/EJMNS/article/view/76716

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