ALGORITHM FOR THE EVALUATION AND MANAGEMENT OF PATIENTS WITH MISCARRIAGE ASSOCIATED WITH HORMONAL DISORDERS
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Abstract:
Miscarriage is a significant challenge in modern reproductive medicine, occurring in approximately 10–20% of clinically diagnosed pregnancies. Hormonal disturbances play a crucial role in its development, including luteal phase deficiency, thyroid dysfunction, hyperprolactinemia, and hyperandrogenism. The aim of this study was to develop an algorithm for the evaluation and management of patients with miscarriage associated with endocrine disorders, based on an analysis of current international guidelines and scientific evidence. A review of the literature published between 2018 and 2025 was conducted. It was established that the contemporary approach is based on early diagnosis (after two pregnancy losses), selective hormonal screening, and personalized therapy. An algorithm was developed incorporating stages of diagnosis, risk stratification, and therapeutic decision-making. The application of an algorithm-based approach improves clinical management and reduces the incidence of reproductive loss.
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