Eurasian Journal of Medical and Natural Sciences

Cardiotoxicity as a complication of antitumor therapy remains a serious problem in cardiology and oncohematology, limiting the use of effective chemotherapeutic and targeted agents and worsening the clinical prognosis of patients. Oxidative stress, which leads to cardiomyocyte damage, impaired contractile function, and the development of electrical instability, is considered one of the key mechanisms of cardiotoxic damage. In recent years, particular attention has been paid to ferroptosis, an iron-dependent form of regulated cell death caused by the accumulation of lipid peroxidation products

This article presents the results of studying the qualitative and quantitative composition of amino acids in the aerial parts of dyestuff safflower (Carthamus tinctorius L.) grown in Uzbekistan. The analysis revealed the presence of 20 amino acids in the raw material, 10 of which are essential amino acids. Considering the diversity and relatively high content of amino acids, the aerial parts of this annual plant can be recommended as a natural source that exerts a complex effect on the body, contributing to the normalization of the functioning of multiple physiological systems.

This article studies the possibilities of accelerating the process of oil extraction from flax seeds using the pressing method. The study analyzes the influence of factors such as temperature, pressure, pressing time, and seed moisture on the level of oil extraction. Based on practical results, optimal technological regimes are identified, and ways to reduce energy consumption and increase production efficiency are proposed. The article serves to introduce efficient and economical oil production technologies in the food industry.

Endometrial hyperplastic processes in premenopausal women represent a common gynecological condition associated with hormonal imbalance, abnormal uterine bleeding, impaired quality of life, and an increased risk of endometrial cancer.

Menstrual cycle disorders are among the most common gynecological problems in women of reproductive age and are closely associated with age-related changes in hormonal regulation. Comparative evaluation of hormonal profiles across reproductive age groups is essential for understanding the pathogenesis of these disorders.

To perform a comparative clinical analysis of biochemical and ultrasonographic markers of ovarian reserve in women of different reproductive age groups.

To evaluate the diagnostic value of hormonal and ultrasound markers in the early detection of fibrocystic mastopathy associated with ovarian cysts.

Fetal growth restriction (FGR) is a major challenge in perinatal medicine, associated with increased perinatal morbidity and mortality. Early identification of FGR is essential for optimizing pregnancy management and improving perinatal outcomes.

Premenstrual syndrome (PMS) is a common neuroendocrine disorder among women of reproductive age and significantly impairs quality of life. Identification of reliable clinical and hormonal predictors of PMS severity remains a key challenge in modern gynecology.

This study investigated the technological properties of a compressible mass intended for tablets used in the treatment of urolithiasis. Dry extracts of Rubia tinctorum (Bo‘yoqdor ro‘yan) was selected as active substance. Initial tests revealed unsatisfactory technological indicators: uneven particle size distribution, poor flowability, high compressibility coefficient, and excessive residual moisture. Application of the wet granulation method with lactose and starch as excipients significantly improved the mass properties, enhancing flowability, compressibility, and moisture balance. The obtained results provide a strong basis for producing stable and high-quality tablets in further stages of development.

Abdominoperineal resection (APR) remains a standard surgical approach for patients with low rectal adenocarcinoma when sphincter preservation is not oncologically feasible. Despite its effectiveness in achieving local disease control, APR is associated with a high incidence of postoperative male sexual dysfunction, primarily erectile dysfunction and ejaculatory disorders. These complications arise mainly from injury to the pelvic autonomic nervous system during deep pelvic dissection. This article reviews the anatomical and pathophysiological mechanisms underlying sexual dysfunction after APR, evaluates nerve-sparing surgical strategies, and summarizes clinical evidence on functional outcomes. A narrative analysis of published clinical studies indicates that preservation of the hypogastric nerves and pelvic plexus significantly improves postoperative sexual function without compromising oncologic radicality in selected patients. Comprehensive preoperative assessment and structured postoperative rehabilitation are essential components of patient-centered care. Integrating nerve-sparing principles into APR, when oncologically safe, can mitigate sexual morbidity and improve long-term quality of life.

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of the connective tissue, often accompanied by metabolic disturbances that significantly affect disease progression and long-term prognosis. Metabolic syndrome (MS), characterized by insulin resistance, dyslipidemia, abdominal obesity, and arterial hypertension, is increasingly recognized as an important comorbid factor in patients with RA.

The increasing incidence of liver pathologies has intensified the need for the development of new-generation hepatoprotective agents in modern pharmacology. This article analyzes the biological significance of hepatoprotective combinations developed on the basis of synthetic drug substances and infusion solutions. The effects of a combination consisting of monoammonium glycyrrhizinate, glycine, and L-cysteine hydrochloride on hepatocyte stability, antioxidant system activity, and endogenous detoxification mechanisms are examined. The biological synergy of the components is scientifically substantiated as a factor that enhances the effectiveness of complex therapy for liver and biliary system diseases.

This article presents methods of working in comfortable working conditions for workers, measures to create a healthy working environment based on the rules established by the Labor Code, and measures to prevent the occurrence of occupational diseases.

Nonobstructive azoospermia (NOA) is one of the most severe forms of male infertility, and effective treatment methods are limited. In recent years, the use of platelet-rich plasma (PRP) in regenerative medicine has been expanding. The aim of this study is to standardize autologous platelet-rich plasma in patients with NOA in clinical, experimental, and transfusion terms and to evaluate its effect on spermatogenesis. In the study, leukoreduced P-PRP was prepared in 48 patients aged 22-45 years with NOA, and its cellular composition, growth factor content, and clinical efficacy were studied. The results showed that PRP is a promising method for stimulating spermatogenesis.

From the aerial part of the plant Onobrychis grandis Lipsky (Fabaceae) growing in the territory of Uzbekistan, the phenolic glycoside arbutin was isolated. The parameters of the acute toxicity of arbutin were determined, its analgesic activity was studied in the tests “hot plate,” “acetic writhing” and “acetylcholine writhing.” It was shown that arbutin belongs to low-hazard substances (Class IV according to GOST 12.1.007-76) and practically non-toxic compounds (Class VI according to the classification of A.V. Stefanov). The compound showed pronounced analgesic activity in thermal and chemical (acetic acid) irritation, but did not show a significant effect in the acetylcholine writhing test.

The article presents the results of research on the development of a method for the quantitative determination of inulin in the roots of Arctium leospermum L.   growing in Uzbekistan.  For this purpose, a spectrophotometric method was used. The data obtained were statistically processed.

This article investigates the anti-inflammatory effect of mixtures prepared from the medicinal plants sage (Salvia officinalis L.) and chamomile (Matricaria chamomilla L.) in a model of acute carrageenan-induced inflammation. During the study, the richness of sage and chamomile in bioactive substances, their mechanisms of action on the inflammatory process, and the pharmacological efficacy of the mixtures prepared in various ratios were evaluated. The results showed that the sage and chamomile mixture possesses significant anti-inflammatory activity, leading to a reduction in edema and signs of inflammation in experimental animals. This mixture could be utilized as a natural anti-inflammatory agent in the future.

The methods of determination and identification of klozapin by the approach of thermodesorption surface-ionizing spectroscopy were worked out. It was established that alcoholic solutions of klozapin has maximum absorbtion at ~180±15°С and ~270±15°С. The linear-dynamic range is in the interval concentration of 5,0-50,0 mkg/ml of substance in the sample. Sensitivity of the method is 10 ng. Worked out method was applied for analysis of klozapine  in expert objects.

The aim of this review is to analyze endoprosthetic reconstruction as a reconstructive method within limb-sparing surgical treatment of primary bone tumors. Data from national and international studies addressing endoprosthetic reconstruction in osteosarcoma, Ewing sarcoma, chondrosarcoma, and giant cell tumor of bone are summarized. Key anatomical localizations, principles for selecting endoprosthetic designs, and factors influencing functional outcomes, including complications and rehabilitation-related aspects, are discussed. Current trends and future perspectives in orthopedic oncologic endoprosthetics are also reviewed

Menstrual cycle disorders are among the most common gynecological problems in adolescent girls and are closely linked to psychoemotional instability characteristic of this age. Neuroendocrine changes, emotional sensitivity, and vulnerability to stress during adolescence may disrupt the hypothalamic–pituitary–ovarian axis, leading to functional menstrual irregularities. This review examines the role of psychoemotional factors—such as chronic stress, anxiety, depressive symptoms, and social maladaptation—in the development of menstrual disorders, including oligomenorrhea, amenorrhea, dysmenorrhea, and dysfunctional uterine bleeding. Based on recent clinical and epidemiological studies, the analysis emphasizes psychosomatic mechanisms and stress-induced hormonal imbalance. The findings underscore the importance of early identification of psychoemotional stressors and a multidisciplinary approach integrating psychological support with medical management to improve outcomes and quality of life in adolescent girls.

This is the first report on the chemical composition of essential oils from Dipsacus azureus Schrenk. The essential oil was obtained from dried raw materials collected during the flowering phase. According to chromatograph mass spectrometry, the main components of the essential oil are camphor (14.14%), p-Mentha-1,4(8)-diene (3.28%), 2-furancarboxaldehyde (3.96%), camphene (4.11%), (+)-4-carene (6.75%), d-limonene (11.05%), and eucalyptol (24.90%).

This article provides an in-depth scientific analysis of the chemical composition of sesame seeds (Sesamum indicum L.), with a particular focus on their biologically active compounds and therapeutic properties. The study examines unsaturated fatty acids, lignans (sesamin, sesamolin, sesamol), vitamins, and mineral elements, highlighting their effects on metabolic processes, cardiovascular health, bone tissue, digestive function, and hormonal balance. In addition, the antioxidant, anti-inflammatory, and immunomodulatory properties of sesame are substantiated based on relevant scientific literature. The findings demonstrate that the inclusion of sesame and sesame-derived products in a balanced diet plays a significant role in promoting human health and preventing chronic diseases.

This article presents the results of research on the development of a syrup preparation technology based on plant raw materials with anti-anemic properties. The aim was to select biologically active components of plant origin, containing iron, vitamins and organic acids, which have the property of stimulating hematopoiesis processes. A technological scheme for syrup production was developed, its physicochemical, organoleptic and microbiological properties were evaluated. The possibilities of using the developed product as a functional food product and auxiliary agent in the prevention and complex treatment of anemia were demonstrated.

To develop and validate a prognostic model for stratifying the risk of severe course of type 1 diabetes mellitus (T1DM) in children after COVID-19.

This article analyzes and classifies the initial research on the study, development, and treatment methods of stomatology, one of the important branches of medicine, in ancient Eastern medicine. In particular, the specific features of dental diseases, their treatment, and prevention in ancient China, India, and Central Asia are shown. The article also focuses on the emergence and development of dentistry in Central Asia and some aspects of natural treatment methods.

Anemia remains one of the most common pathologies in clinical practice and represents a significant medical and social problem affecting various age and clinical groups. Iron deficiency is the leading cause of anemic conditions in many cases, leading to the widespread use of iron supplements for therapeutic and prophylactic purposes

Preeclampsia (PE) remains one of the most significant challenges in modern obstetrics, as it is associated with a high risk of preterm birth, intrauterine growth restriction, increased perinatal and maternal mortality, and frequent admissions of newborns to intensive care units. In addition to acute complications, PE is linked to long-term adverse outcomes for both maternal and child health. In recent years, a major breakthrough in identifying women at risk for PE has been achieved through the implementation of the Fetal Medicine Foundation (FMF) screening model. This approach, which integrates anamnesis-based, biophysical, and biochemical parameters, is now widely used in many countries, including Russia and Uzbekistan, and has significantly improved early prediction of preeclampsia.

Anise hyssop (Agastache foeniculum (Pursh) Kuntze, synonym Lophanthus anisatus Benth.) is considered a promising source of biologically active compounds with multidirectional pharmacological effects. This review article, for the first time, systematizes and summarizes data on the anti-inflammatory activity of Agastache foeniculum from the perspective of the relationship between its chemical composition and the molecular mechanisms of inflammation. It is shown that phenolic compounds and essential oil components of the plant are capable of modulating oxidative stress, the expression of pro-inflammatory cytokines, and signaling pathways associated with NF-κB activation. Particular attention is paid to studies conducted by Uzbek scientists, which form the scientific and raw material basis for further pharmaceutical development. The presented analysis confirms the feasibility of in-depth preclinical studies and standardization of Agastache foeniculum extracts as a potential source of anti-inflammatory phytomedicines

Tirsion deformity of the legs in children is a common orthopedic problem that can have long-therm effects on gait, posture, and joint health. This article reviews the etiology, clinical presentation, and modern diagnostic methods, such as computed tomography (CT) and giat analysis, to accurately indentify deformities such hip anteversion and calf torsion. It also discusses modern treatments, including conservative treatments such as orthopedics and physiotherapy, and surgical methods such as hip and calf deformation osteotomy. The emphasis is early diagnosis and individualized treatment plans to ensure good functional outcomes and prevent complications in adulthood.

Systemic Hemorrhagic vasculitis (Henoch–Schönlein purpura) is an immune-mediated small-vessel vasculitis characterized by multisystem involvement, including skin, joints, gastrointestinal tract, and kidneys. The clinical course and prognosis of the disease largely depend on the predominant clinical form and severity of organ involvement. Basic therapy remains the cornerstone of treatment; however, its effectiveness varies among different clinical presentations.

This review summarizes recent advances and clinical evidence on methods and agents of local anesthesia in dentistry over the past 5–10 years. Particular attention is paid to the comparative efficacy of amide local anesthetics (articaine, lidocaine, and others), the effect of solution buffering on onset time and injection comfort, modern delivery techniques (intraosseous anesthesia, computer-controlled local anesthetic delivery systems—CCLAD/QuickSleeper, and single-tooth anesthesia), as well as safety issues including adverse effects and the risk of paresthesia. Key findings and practical recommendations for clinicians regarding the selection of anesthetic techniques depending on the clinical situation are presented.

Female infertility is a major global health issue, affecting 10–15% of reproductive-age couples. Inflammatory gynecological diseases play a leading role due to their high prevalence, chronic course, and negative impact on the female reproductive system. Conditions such as pelvic inflammatory disease, chronic endometritis, salpingitis, and adnexitis are closely associated with tubal obstruction, impaired endometrial receptivity, ovulatory disorders, and pelvic adhesions, significantly reducing fertility. Persistent inflammation leads to fibrotic changes, immune-endocrine imbalance, and disruption of the reproductive microenvironment. As many of these conditions are asymptomatic, delayed diagnosis increases the risk of infertility. This study emphasizes the importance of early detection, timely treatment, and preventive strategies to improve reproductive outcomes and preserve female reproductive health.

This article provides a scientific analysis of the medicinal properties of essential oil obtained from peppermint (Mentha piperita), with particular emphasis on its antibacterial and antifungal activities. Peppermint essential oil has long been used in traditional medicine for the prevention and treatment of various infectious diseases. The study investigated the chemical composition of peppermint essential oil and the effects of its main bioactive components—menthol, menthone, and other terpenoids—on microorganisms. Antibacterial activity was evaluated using the disk diffusion method, while antifungal activity was assessed based on minimal inhibitory concentration (MIC) values. The results demonstrated that peppermint essential oil exhibits significant inhibitory effects against pathogenic bacteria and fungi. These findings provide a scientific basis for the medicinal properties of peppermint essential oil and expand the possibilities for its application as a natural antimicrobial agent in medicine and pharmaceutical industries.

Postoperative hypothyroidism (overt or subclinical) is one of the most common late-stage conditions in women following thyroid surgery and can significantly reduce quality of life (QOL), even with levothyroxine replacement therapy. Assessing QOL using validated questionnaires allows us to identify the "hidden burden" of symptoms (fatigue, cognitive impairment, anxiety-depressive symptoms, decreased social activity), which do not always correlate with TSH levels alone.

Spinal injuries are a type of injury that affect not only the vertebrae, but also all the surrounding tissues. These include injuries to soft tissues, tendons, ligaments, cartilage, intervertebral discs, nerves, blood vessels, and the spinal cord Therefore, spinal injuries are severe, accompanied by impaired musculoskeletal function and sensitivity, and lead to numerous complications. By choosing the right treatment strategy, we achieved positive outcomes in 17 patients.

This article is devoted to the development of a technology for obtaining a liquid extract based on a multicomponent herbal formulation consisting of medicinal chamomile, calendula, and St. John’s wort, intended for use in inflammatory diseases of the gastrointestinal tract. The study investigates the factors affecting the extraction process, evaluates the quality of the newly developed dosage form, and identifies the biologically active substances contained in the extract.

This article presents the development of a new technology for obtaining a liquid extract from a complex herbal formulation based on the plant Bidens tripartita L., which possesses anti-allergic activity. The study also reports the determination of the qualitative and quantitative parameters of the obtained liquid extract, as well as the results of the quantitative analysis of bioactive compounds. During the production of the liquid extract, factors influencing the release of bioactive substances from medicinal plant raw materials—such as the degree of grinding of the plant material, the extraction efficiency of the solvent, and the hydromodule—were investigated. Based on the selection of optimal extraction conditions, the parameters ensuring the maximum yield of bioactive compounds were established.

This paper highlights the role of structural and functional placental alterations in the development of pregnancy complications, including preeclampsia, fetal growth restriction, and placental insufficiency.