SOXTA KASHTAN PO‘STLOG‘IDAN ESKULIN VA FRAKSIN KUMARINLARINI AJRATIB OLISH
Abstrak
Soxta kashtan urug‘lari tarkibida ko‘p biofaol moddalar mavjudligi sababli farmatsevtika sanoati uchun zarur xomashyolardan biridir. Jumladan, uning tarkibida triterpen glikozidlar (essin va uning hosilalari), kumarinlar, flavonoidlar, lipidlar va boshqa birikmalar uchraydi [1]. Soxta kashtanning asosiy biofal moddasi bo‘lgan essin va uning hosilalari asosida tibbiyotda venatonik, yallig‘lanish va shishga qarshi yigirmaga yaqin dori vositalar olingan [2]. Kumarinlar kuchli antikogulyant xususiyatga ega bo’lib, qonning ivishini sekinlashtiradi [3]. Ushbu omillar sifatni ta’minlashda bosqichli sifat nazoratini takomillashtirishni taqozo etadi.
Iqtiboslar
Fazliev S. et al. Escin’s Multifaceted Therapeutic Profile in Treatment and Post-Treatment of Various Cancers: A Comprehensive Review //Biomolecules. – 2023. – Т. 13. – №. 2. – С. 315.
Gallelli L. Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties //Drug design, development and therapy. – 2019. – С. 3425-3437.
Verhoef T. I. et al. Pharmacogenetic guided dosing of coumarin anticoagulants: algorithms for warfarin, acenocoumarol and phenprocoumon //British journal of clinical pharmacology. – 2014. – Т. 77. – №. 4. – С. 626-641.
Matysik G. et al. Chromatography of esculin from stems and bark of Aesculus hippocastanum L. for consecutive vegetative periods //Chromatographia. – 1994. – Т. 38. – С. 766-770.
