GEM SINTEZI BUZILISHINING YURAK YETISHMOVCHILIGI RIVOJLANISHIGA TA’SIRI
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CHF, ID, CKD, gem, sitoxrom P450, ferment, kislorod, gemoglobin, yurak yetishmovchiligi, temir tanqisligi, kamqonlik, ALAS2.Abstrak
Surunkali yurak etishmovchiligi (CHF) va temir tanqisligi (ID) anemiya bilan bog'lanishi hozirgi tibbiy amaliyotda tez-tez uchraydi va salbiy prognostik ta'sir ko'rsatadi, bemorlarning jismoniy mashqlar qobiliyatini yomonlashtiradi. Bundan tashqari, surunkali buyrak kasalligi (CKD) va CHF bilan og'rigan bemorlarda anemiya keng tarqalgan bo'lib, kardio-renal anemiya sindromi (CRAS) deb nomlanuvchi assotsiatsiya o'lim xavfini sezilarli darajada oshiradi. Maqsad: Ushbu maqolada CHF bilan funktsional va mutlaq ID o'rtasidagi bog'liqlik asosida CHF bemorlarida IDning ta'siri va CHFda temir qo'shimchasining foydasi haqida taqdim etishga qaratilgan. Murakkab fiziopatologik o'zaro ta'sir tasvirlangan - eritropoetin darajasining pasayishi, renin angiotensin-aldosteron tizimining faollashishi. Ushbu mexanizmlar anemiya, CHF va CKD kasalliklarni kuchaytiradi va bemorlarning natijalarini yomonlashtiradi.
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