THE IMPORTANCE AND RELEVANCE OF IMMUNOINFORMATICS IN MODERN MEDICAL PRACTICE OF DISEASE PREVENTION AND TREATMENT
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Abstrak:
For a number of illnesses, such as cancer, autoimmune disorders and infectious diseases, the immune system is crucial to the creation of tailored treatment. Computational immunology, often known as immunoinformatics, is a new field that offers basic approaches for studying immunomics, or immune-related proteomics and genomes. A deeper comprehension of immune-related disorders at different systems levels could result from the combination of immunoinformatics and systems biology methodologies. These techniques can support translational research that improves clinical practice by using scientific findings about the immune system. One new medical treatment for breast cancer is vaccination. Cancer vaccines can be developed to teach the immune system to identify tumor cells by focusing on the tumor antigen.
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Rawat SS, Keshri AK, Kaur R, Prasad A. Immunoinformatics Approaches for Vaccine Design: A Fast and Secure Strategy for Successful Vaccine Development. Vaccines (Basel). 2023 Jan 19;11(2):221. doi: 10.3390/vaccines11020221.
Hellysaz, A. & Hagbom, M. Understanding the central nervous system symptoms of rotavirus: A qualitative review. Viruses 13, 658 (2021).
Du, Y. et al. Global burden and trends of rotavirus infection-associated deaths from 1990 to 2019: an observational trend study. Virol. J. 19, 166 (2022).
mondiale de la Santé, O. & World Health Organization. Rotavirus vaccines: WHO position paper–July 2021–Vaccins antirotavirus: note de synthèse de l’OMS–Juillet 2021. Wkly. Epidemiol. Record = Relevé Épidémiologique Hebdomadaire. 96 28, 219–301 (2021).
Hasan, M. et al. Contriving a chimeric polyvalent vaccine to prevent infections caused by herpes simplex virus (type-1 and type-2): an exploratory immunoinformatic approach. J. Biomol. Struct. Dyn. 38, 2898–2915 (2020).
Joshi, A., Joshi, B. C., Mannan, M. A. & Kaushik, V. Epitope based vaccine prediction for SARS-COV-2 by deploying immuno-informatics approach. Inf. Med. Unlocked. 19, 100338 (2020).
Krishnan, G., Joshi, S., Akhtar, A., Kaushik, V. & N. & Immunoinformatics designed T cell multi epitope dengue peptide vaccine derived from Non structural proteome. Microb. Pathog. 150, 104728 (2021).
Devi, Y. D. et al. Exploring rotavirus proteome to identify potential B- and T-cell epitope using computational immunoinformatics. Heliyon 6, e05760 (2020).
Sharma, A. et al. T cell epitope based vaccine design while targeting outer capsid proteins of rotavirus strains infecting neonates: an immunoinformatics approach. J. Biomol. Struct. Dyn. 42, 4937–4955 (2024).
Thakur N, Bailey D. Advances in diagnostics, vaccines and therapeutics for Nipah virus. Microbes Infection. (2019) 21:278–86. doi: 10.1016/j.micinf.2019.02.002
Lo MK, Feldmann F, Gary JM, Jordan R, Bannister R, Cronin J, et al. Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge. Sci Transl Med. (2019) 11:eaau9242. doi: 10.1126/scitranslmed.aau9242
Zafar S, Ajab H, Baig S, Baig A, Habib Z, Jamil F, Ibrahim M, Kanwal S, Rasheed MA. Prediction and evaluation of multi epitope based sub-unit vaccine against Salmonella typhimurium. Saudi J Biol Sci. 2022;29(2):1092–9.
Priyadarsini S, Panda S, Pashupathi M, Kumar A, Singh R. Design of multiepitope vaccine construct against non-typhoidal Salmonellosis and its characterization using immunoinformatics approach. Int J Pept Res Ther. 2021;27(4):2333–48.
Seo H, Duan Q, Zhang W. Vaccines against gastroenteritis, current progress and challenges. Gut Microbes. 2020;11(6):1486–517.
Mancini F, Micoli F, Necchi F, Pizza M, Berlanda Scorza F, Rossi O. GMMA-based vaccines: the known and the unknown. Front Immunol. 2021. https://doi.org/10.3389/fimmu.2021.715393.
Negahdaripour M, Nezafat N, Eslami M, Ghoshoon MB, Shoolian E, Najafipour S, Morowvat MH, Dehshahri A, Erfani N, Ghasemi Y. Structural vaccinology considerations for in silico designing of a multi-epitope vaccine. Infect Genet Evol. 2018;58:96–109.
Goumari, M. M., Farhani, I., Nezafat, N. & Mahmoodi, S. Multi epitope vaccines (MEVs), as a novel strategy against infectious diseases. Curr. Proteom. 17(5), 354–364 (2020).
Bayat, M., Asemani, Y. & Najafi, S. Essential considerations during vaccine design against COVID-19 and review of pioneering vaccine candidate platforms. Int. Immunopharmacol. 97, 107679 (2021).
Kyriakidis, N. C., López-Cortés, A., González, E. V., Grimaldos, A. B. & Prado, E. O. SARS-CoV-2 vaccines strategies: A comprehensive review of phase 3 candidates. NPJ Vaccines 6(1), 28 (2021).
Dixit, N. K. Design of monovalent and chimeric tetravalent dengue vaccine using an immunoinformatics approach. Int. J. Pept. Res. Ther. 27(4), 2607–2624 (2021).
