RHEUMATOID ARTHRITIS: PROBLEMS OF REMISSION AND RESISTANCE TO THERAPY

Abstrak:

Аrthritis (RA) is an immuno–inflammatory (autoimmune) rheumatic disease of unknown etiology, characterized by chronic erosive arthritis and systemic damage to internal organs, leading to early disability and a reduction in the life expectancy of patients. Despite the successes achieved in the treatment of RA associated with the development of new drugs and improving the treatment strategy that allows achieving remission in many patients, there are many theoretical and clinical problems concerning both the definition of the concept of "remission", its characteristics and types, and approaches to the optimal tactics of "symptomatic" and "pathogenetic" drug therapy at different stages of the disease, the use of which will allow you to quickly induce remission and maintain it in the long term.