INVESTIGATION OF OXIDATIVE STRESS MARKERS IN THE PATHOGENESIS OF MYOCARDIAL INFARCTION

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Аннотация:

The investigation of oxidative stress markers in the pathogenesis of myocardial infarction (MI) has received increasing scientific attention because of the pivotal role oxidative stress plays in cardiovascular diseases. Oxidative stress refers to a biochemical imbalance between the production of reactive oxygen species (ROS) and the body’s antioxidant defense mechanisms. When the generation of ROS exceeds the capacity of the antioxidant system, it leads to cellular and molecular damage that contributes to endothelial dysfunction, ischemia, and ultimately, myocardial injury.

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Как цитировать:

Abutalipova, O. . (2025). INVESTIGATION OF OXIDATIVE STRESS MARKERS IN THE PATHOGENESIS OF MYOCARDIAL INFARCTION. Естественные науки в современном мире: теоретические и практические исследования, 4(14), 19–22. извлечено от https://in-academy.uz/index.php/zdtf/article/view/65358

Библиографические ссылки:

Madamanchi, N. R., Vendrov, A., & Runge, M. S. (2005). Oxidative stress and vascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(1), 29–38.

Tsutsui, H., Kinugawa, S., & Matsushima, S. (2011). Oxidative stress and heart failure. American Journal of Physiology-Heart and Circulatory Physiology, 301(6), H2181–H2190.

Packer, M. (2020). Derangements in redox signaling as a major determinant of oxidative stress in heart failure. Circulation, 141(12), 907–929.

Rodrigo, R., Libuy, M., Feliú, F., & Hasson, D. (2013). Oxidative stress-related biomarkers in essential hypertension and ischemia–reperfusion myocardial damage. Disease Markers, 35(6), 773–790.

Dalle-Donne, I., Rossi, R., Colombo, R., Giustarini, D., & Milzani, A. (2006). Biomarkers of oxidative damage in human disease. Clinical Chemistry, 52(4), 601–623.

Patel, R. S., Al Mheid, I., Morris, A. A., Ahmed, Y., Kavtaradze, N., Ali, S., & Alexander, R. W. (2016). Oxidative stress is associated with impaired arterial elasticity in patients with coronary artery disease. Free Radical Biology and Medicine, 97, 319–325.

Griendling, K. K., Touyz, R. M., Zweier, J. L., Dikalov, S., Chilian, W., Chen, Y. R., Harrison, D. G., & Bhatnagar, A. (2016). Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system. Circulation Research, 119(5), e39–e75.

Münzel, T., Camici, G. G., Maack, C., Bonetti, N. R., Fuster, V., & Kovacic, J. C. (2017). Impact of oxidative stress on the heart and vasculature: Part 2—Clinical aspects, drug therapy, and prevention. European Heart Journal, 38(13), 949–959.

Anderson, E. J., Kypson, A. P., Rodriguez, E., Anderson, C. A., Lehr, E. J., & Neufer, P. D. (2009). Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart. Journal of the American College of Cardiology, 54(20), 1891–1898