VARIATION OF HUMORAL IMMUNITY IN MIGRAINES IN CHILDREN AND ADOLESCENTS
Keywords:
Pediatric migraine, humoral immunity, immunoglobulin G, immunoglobulin M, circulating immune complexes, immune imbalance, migraine with aura, immunopathogenesis.Abstract
Migraine in children and adolescents is increasingly being recognized not only as a neurological disorder, but also as a condition with possible immune system involvement. This paper explores the role of humoral immunity in the pathogenesis and clinical presentation of pediatric migraine. Based on the study of 42 children aged 6 to 18 with various forms of migraine, significant differences in immunoglobulin levels and circulating immune complexes (CIC) were observed. These findings suggest the presence of immune imbalance in children with migraines, especially those with aura. Understanding the immunological aspects of migraine can contribute to improved diagnostics, prognostics, and the development of personalized therapeutic strategies.
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