РОЛЬ ИНСУЛИНОРЕЗИСТЕНТНОСТИ В ПАТОГЕНЕЗЕ ИШЕМИЧЕСКОГО ИНСУЛЬТА
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Аннотация:
Ишемический инсульт остается одной из ведущих причин смертности и длительной инвалидности во всем мире, несмотря на успехи в неотложной помощи и коррекции факторов риска. Инсулинорезистентность (ИР), традиционно ассоциируемая с сахарным диабетом 2 типа, стала независимым, модифицируемым фактором риска ишемического инсульта. Помимо метаболических последствий, ИР способствует эндотелиальной дисфункции, ускоряет атеросклероз, усиливает тромбообразование и усиливает нейровоспалительные и окислительные процессы, тем самым влияя как на частоту развития инсульта, так и на его прогноз. В данном обзоре обобщены современные данные о роли ИР в патогенезе ишемического инсульта, включая эпидемиологические данные, молекулярные механизмы и потенциальное клиническое применение.
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