ISHEMIK INSULT PATOGENEZIDA INSULINGA CHIDAMLILIKNING ROLI
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Abstrak:
O‘tkir aralashuvlar va xavf omillarini boshqarishdagi yutuqlarga qaramay, ishemik insult butun dunyo bo‘ylab o‘lim va uzoq muddatli nogironlikning asosiy sababi bo‘lib qolmoqda. Insulinga rezistentlik (IR) - an’anaviy ravishda 2-toifa qandli diabet bilan bog‘liq - ishemik insult uchun mustaqil, o‘zgartiriladigan xavf omili sifatida paydo bo‘ldi. Metabolik ta’siridan tashqari, IR endotelial disfunksiyani rag‘batlantiradi, aterosklerozni tezlashtiradi, trombogenezni kuchaytiradi, neyroyallig‘lanish va oksidlanish jarayonlarini kuchaytiradi va shu bilan insult bilan kasallanish va prognozga ta’sir qiladi. Ushbu sharh epidemiologik ma'lumotlarni, molekulyar mexanizmlarni va potentsial klinik ilovalarni birlashtirgan ishemik insult patogenezida IR ning roli haqidagi mavjud dalillarni sintez qiladi.
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