CLINICAL AND DIAGNOSTIC FEATURES AND EFFECTIVENESS OF SURGICAL TREATMENT OF MESIAL TEMPORAL LOBE EPILEPSY
##plugins.themes.bootstrap3.article.sidebar##
##plugins.themes.bootstrap3.article.main##
Abstrak:
Despite certain successes in the treatment of epilepsy, primarily associated with the active development of pharmacology, in 30% of cases its resistant course is noted, especially focal forms of temporal epilepsy. One of the main causes is mesial temporal sclerosis (MTS), considered an absolute epileptogenic substrate, not amenable to conservative treatment in 90-92% of cases. Surgical treatment seems to be the only method that helps improve the quality of life of such patients. However, the percentage of surgical care for epilepsy remains low. Structured information on clinical manifestations, diagnostic methods, approaches to surgical treatment and its outcomes should contribute to understanding the problem among specialists. Data on the effectiveness of operations in patients with drug-resistant epilepsy can help in timely provision of high-tech care to patients with mesial temporal epilepsy.
##plugins.themes.bootstrap3.article.details##
##submission.howToCite##:
##submission.citations##:
Abduvoyitov, B. (2025). FARMAKOREZISTENT EPILEPSIYA BILAN OG'RIGAN BEMORLARNING JARROHLIK DAVOLASH NATIJALARI VA QONIQARSIZ JARROHLIK NATIJALARINI BASHORAT QILUVCHI OMILLAR. Modern Science and Research, 4(2), 91-92.
Abduvoyitov, B. (2025). POLIMIKROGIRIYALI FARMAKOREZISTENT EPILEPSIYANI DAVOLASH NATIJALARI. Modern Science and Research, 4(2), 117-121.
Abduvoyitov, B. (2025). FARMAKOREZISTENT EPILEPSIYADA STEROIDLARNING AHAMIYATI. Medical Research Journal, 1(1), 244-250.
Abduvoyitov, B. (2025). MRT ASOSIDA FARMAKO REZITENT EPILEPSIYANI TASHXISLASH VA NATIJALARNI PROGNOZ QILISH: ZAMONAVIY YONDASHUVLAR. Medical Research Journal, 1(1), 215-219.
Мамадалиев, А. М., Алиев, М. А., Абдувойитов, Б. Б. У., Хайритдинов, Б. Б., Фарухова, М. Ф., Гаппарова, О. И., ... & Бурхонов, А. Ш. (2022). Клинический cлучай риносинусогенного абсцесса головного мозга и обзор литературы. Uzbek journal of case reports, 2(2), 7-11.
Bahodirovich A. B. et al. Approaches to intestinal decompression during different appendicular peritonitis in children //Достижения науки и образования. – 2018. – №. 18 (40). – С. 92-95.
Djalolov D. A. et al. Features of microflora in the etiological structure of diffuse appendicular peritonitis //Вопросы науки и образования. – 2018. – Т. 8. – №. 2. – С. 116.
Abduvoyitov Bobur Bahodirovich, Djalolov Davlatshokh Abduvokhidovich, Khasanov Aziz Batirovich, Abbasov Khojimuhammad Khabibullayevich The effect of ozone on the course and development of complications of peritonitis in children // Вопросы науки и образования. 2018. №29 (41).
Abduvoyitov B. B. et al. The effect of ozone on the course and development of complications of peritonitis in children //Вопросы науки и образования. – 2018. – Т. 29. – С. 110-113.
Bahodirovich A. B. et al. Immunological feature of the body in children with diffused appendicular peritonitis //Вопросы науки и образования. – 2019. – №. 2 (45). – С. 115-122.
Blümcke I., Thom M., Aronica E. et al. International consensus clas-
sification of hippocampal sclerosis in temporal lobe epilepsy: a Task
Force report from the ILAE Commission on Diagnostic Methods //
Epilepsia. 2013. Vol. 54, No 7. P. 1315–29. Doi: 10.1111/epi.12220.PMID: 23692496.
Fisher R. S., Cross J. H., French J. A. Et al. Operational classification
of seizure types by the International League Against Epilepsy: Position
Paper of the ILAE Commission for Classification and Terminology //
Epilepsia. 2017. Vol. 58, No 4. P. 522–530. Doi: 10.1111/epi.13670.PMID: 28276060.
Ye B. S., Cho Y. J., Jang S. H. et al. The localizing and lateralizing value of auras in lesional partial epilepsy patients // Yonsei Med J. 2012. Vol. 53, No 3. P. 477–85. Doi: 10.3349/ymj.2012.53.3.477. PMID: 22476989; PMCID: PMC3343447.
Mani J. Video electroencephalogram telemetry in temporal lobe epilepsy // Ann Indian Acad Neurol. 2014. Vol. 17(Suppl 1). P. 45–49. Doi: 10.4103/0972-2327.128653. PMID: 24791089; PMCID: PMC4001214.
Guo X., Xu S., Wang G., Zhang Y., Guo L., Zhao B. Asymmetry of
cerebral blood flow measured with three-dimensional pseudocontinuous arterial spin-labeling mr imaging in temporal lobe epilepsy with and without mesial temporal sclerosis // J Magn Reson Imaging. 2015. Vol. 42, No 5. P. 1386–97. Doi: 10.1002/jmri.24920. PMID: 25884243.
Lin K., Carrete H., Lin J. et al. Facial paresis in patients with mesial
temporal sclerosis: clinical and quantitative MRI-based evidence of
widespread disease // Epilepsia. 2007. Vol. 48, No 8. P. 1491–9. Doi:
1111/j.1528-1167.2007.01076.x. PMID: 17433056.
Duncan J. S. Imaging in the surgical treatment of epilepsy // Nat Rev
Neurol. 2010. Vol. 6, No 10. P. 537–50. Doi: 10.1038/nrneurol.2010.131.
PMID: 20842185.
Stefanits H., Springer E., Pataraia E. et al. Seven-Tesla MRI of Hip-
pocampal Sclerosis: An In Vivo Feasibility Study With Histological
Correlations // Invest Radiol. 2017. Vol. 52, No 11. P. 666–671. Doi:
1097/RLI.0000000000000388. PMID: 28538339.
De Ciantis A., Barba C., Tassi L. et al. 7T MRI in focal epilepsy with un-
revealing conventional field strength imaging // Epilepsia. 2016. Vol. 57,
No 3. P. 445–54. Doi: 10.1111/epi.13313. PMID: 26778405.
Engel J. Jr, Thompson P. M. Going beyond hippocampocentricity in the
concept of mesial temporal lobe epilepsy // Epilepsia. 2012. Vol. 53, No 1.
P. 220–3. Doi: 10.1111/j.1528-1167.2011.03366.x. PMID: 22221162.
Javan R., Schickel M., Zhao Y. et al. Using 3D-Printed Mesh-Like Brain
Cortex with Deep Structures for Planning Intracranial EEG Electrode
Placement // J Digit Imaging. 2020. Vol. 33, No 2. P. 324–333. Doi:
1007/s10278-019-00275-3. PMID: 31512018.
Najm I. M. Mapping brain networks in patients with focal epilepsy //
Lancet Neurol. 2018. Vol. 17, No 4. P. 295–297. Doi: 10.1016/S1474-
(18)30090-5. PMID: 29553374.
Хачатрян В. А., Маматханов М. Р., Лебедев К. Э. Инвазивный ЭЭГ-
мониторинг в системе хирургического лечения эпилепсии у детей //
Российский нейрохирургический журнал им. проф. А. Л. Поленова.
Т. 4, No 4. С. 22–27.
Денисова Н. П., Рогов Д. Ю., Халепа А. А. Хирургическое лечение
мезиальной височной эпилепсии с использованием интраопера-
ционной и хронической электрокортикографии // Нейрохирургия.
No 3. С. 20–26.
Hutchison R. M., Womelsdorf T., Allen E. A. et al. Dynamic functional
connectivity: promise, issues, and interpretations // Neuroimage. 2013.
Vol. 80. P. 360–78. Doi: 10.1016/j.neuroimage.2013.05.079. PMID:
; PMCID: PMC3807588.
Ryvlin P., Cross J. H., Rheims S. Epilepsy surgery in children and adults // Lancet Neurol. 2014. Vol. 13, No 11. P. 1114–1126. Doi: 10.1016/
S1474-4422(14)70156-5. PMID: 25316018.
Schramm J., Lehmann T. N., Zentner J. et al. Randomized controlled
trial of 2.5-cm versus 3.5-cm mesial temporal resection in temporal lobe
epilepsy – Part 1: intent-to-treat analysis // Acta Neurochir (Wien). 2011.
Vol. 153, No 2. P. 209–19. Doi: 10.1007/s00701-010-0900-6. PMID:
Boon P., De Cock E., Mertens A., Trinka E. Neurostimulation for drug-
resistant epilepsy: a systematic review of clinical evidence for efficacy,
safety, contraindications and predictors for response // Curr Opin Neurol.
Vol. 31, No 2. P. 198–210. Doi: 10.1097/WCO.0000000000000534.
PMID: 29493559.
Engel J. Jr. Update on surgical treatment of the epilepsies. Summary
of the Second International Palm Desert Conference on the Surgical
Treatment of the Epilepsies (1992) // Neurology. 1993. Vol. 43, No 8.
P. 1612–7. Doi: 10.1212/wnl.43.8.1612. PMID: 8102482.
Wieser H. G., Blume W. T., Fish D. Commission on Neurosurgery of
the International League Against Epilepsy (ILAE). ILAE Commission
Report. Proposal for a new classification of outcome with respect to
epileptic seizures following epilepsy surgery // Epilepsia. 2001. Vol. 42,
No 2. P. 282–6. PMID: 11240604.
Mathon B., Bielle F., Samson S. et al. Predictive factors of long-term
outcomes of surgery for mesial temporal lobe epilepsy associated with
hippocampal sclerosis // Epilepsia. 2017. Vol. 58, No 8. P. 1473–1485.
Doi: 10.1111/epi.13831. PMID: 28656696.
Mathon B., Bédos U. L, Adam C. et al. Surgical treatment for mesial
temporal lobe epilepsy associated with hippocampal sclerosis // Rev
Neurol (Paris). 2015. Vol. 171, No 3. P. 315–25. Doi: 10.1016/j.neu-rol.2015.01.561. PMID: 25746582.
Крылов В. В., Гехт А. Б., Трифонов И. С. и др. Исходы хирургического
лечения пациентов с фармакорезистентными формами эпилепсии //
Журн. неврологии и психиатрии им. С. С. Корсакова. 2016. Т. 116,
No 9–2. С. 13–18. Doi: 10.17116/jnevro20161169213-18.
Касумов В. Р., Берснев В. П., Касумов Р. Д. Транскортикальная
амигдалогиппокампэктомия в лечении фармакорезистентной эпи-
лепсии // Креативная хирургия и онкология. 2011. Т. 1. С. 62–65.
Schmeiser B., Daniel M., Kogias E. et al. Visual field defects following dif-
ferent resective procedures for mesiotemporal lobe epilepsy // Epilepsy
Behav. 2017. Vol. 76. P. 39–45. Doi: 10.1016/j.yebeh.2017.08.037.
PMID: 28954709.
Feng E. S., Sui C. B., Wang T. X., Sun G. L. Stereotactic radiosurge-
ry for the treatment of mesial temporal lobe epilepsy // Acta Neurol
Scand. 2016. Vol. 134, No 6. P. 442–451. Doi: 10.1111/ane.12562. PMID:
Крылов В. В., Рак В. А., Токарев А. С. и др. Стереотаксическая
радиохирургия в комплексном лечении пациентов с эпилепсией, ас-
социированной с различными структурными поражениями головного
мозга // Неотложная мед. помощь : Журн. им. Н. В. Склифосовского.
Т. 10, No 1. С. 73–82. Doi: 10.23934/2223-9022-2021-10-1-73-82.
Касумов В. Р. Ближайшие и отдаленные результаты хирургического
лечения многоочаговой эпилепсии // Бюллетень сибирской меди-
цины. 2009. Т. 8, No 1(2). С. 42–45. Doi:10.20538/1682-0363-2009-
(2)-42-45.
McGonigal A., Sahgal A., De Salles A. et al. Radiosurgery for epilepsy:
Systematic review and International Stereotactic Radiosurgery Society
(ISRS) practice guideline // Epilepsy Res. 2017;137:123–131. Doi:
1016/j.eplepsyres.2017.08.016. PMID: 28939289.
Bezchlibnyk Y. B., Willie J. T., Gross R. E. A neurosurgeon`s view: Laser
interstitial thermal therapy of mesial temporal lobe structures // Epilepsy
Res. 2018;142:135–139. Doi: 10.1016/j.eplepsyres.2017.10.015. PMID:
King-Stephens D. What Is the Best Target for Ablation of Mesial Temporal
Lobe Epilepsy? // Epilepsy Curr. 2019. Vol. 19, No 5. С. 313–315. Doi:
1177/1535759719868460. PMID: 31409148; PMCID: PMC6864567.
Kang J. Y., Wu C., Tracy J. et al. Laser interstitial thermal therapy
for medically intractable mesial temporal lobe epilepsy // Epilepsia. 2016.
Vol. 57, No 2. С. 325–34. Doi: 10.1111/epi.13284. PMID: 26697969.
Bourdillon P., Cucherat M., Isnard J. et al. Stereo-electroencephalography-
guided radiofrequency thermocoagulation in patients with focal epilepsy:
A systematic review and meta-analysis // Epilepsia. 2018. Vol. 59, No 12.
С. 2296–2304. Doi: 10.1111/epi.14584. PMID: 30345535.
Toth M., Papp K. S., Gede N. et al. Surgical outcomes related to invasive
EEG monitoring with subdural grids or depth electrodes in adults: A
systematic review and meta-analysis // Seizure. 2019. Vol. 70. P. 12–19.
Doi: 10.1016/j.seizure.2019.06.022.
Willems L. M., Reif P. S., Spyrantis A. et al. Invasive EEG-electrodes
in presurgical evaluation of epilepsies: Systematic analysis of implantation-, video-EEG-monitoring- and explantation-related complications,
and review of literature // Epilepsy Behav. 2019. Vol. 91. P. 30–37. Doi:
1016/j.yebeh.2018.05.012. PMID: 29907526.