MIKROTSIRKULYATSIYA BUZILISHLARINING ICHKI A’ZOLAR KASALLIKLARI PATOGENEZIDAGI O‘RNI
Article Sidebar
Main Article Content
Аннотация:
Mikrotsirkulyatsiya — bu organizmdagi eng nozik qon tomirlari tarmog‘i bo‘lib, arteriolalar, kapillyarlar va venulalardan iborat. U organ va to‘qimalarga kislorod, glyukoza, aminokislotalar va boshqa oziqa moddalarini yetkazish hamda metabolik chiqindilarni olib chiqishda asosiy rol o‘ynaydi. Mikrotsirkulyatsiya buzilishi turli ichki a’zolarda patofiziologik jarayonlarning rivojlanishiga bevosita ta’sir ko‘rsatadi. Shu jumladan, qandli diabet, gipertenziya, yurak-qon tomir kasalliklari, buyrak yetishmovchiligi va boshqa surunkali patologiyalarda mikroangiopatiya, endotelial disfunktsiya va kapillyar perfuziya buzilishi aniqlanadi. Ushbu maqolada mikrotsirkulyatsiya buzilishining mexanizmlari, uning ichki a’zolar kasalliklari patogenezidagi roli, bemorlar orasida kuzatilgan klinik belgilar va laboratoriya ko‘rsatkichlari tahlil qilinadi. Shuningdek, turli kasalliklar kontekstida mikrotsirkulyatsiyani normallashtirishning profilaktik va terapevtik yondashuvlari ham ko‘rib chiqiladi. Mikrotsirkulyatsiya buzilishining o‘rganilishi ichki a’zolar kasalliklarini erta tashxislash, asoratlarning oldini olish va davolash strategiyalarini optimallashtirish uchun zarurdir.
Article Details
Как цитировать:
Библиографические ссылки:
Pries, A. R., Secomb, T. W., & Gaehtgens, P. (2000). Structural adaptation and stability of microvascular networks: Theory and simulations. American Journal of Physiology–Heart and Circulatory Physiology, 275(2), H349–H360.
Granger, D. N., & Senchenkova, E. (2010). Inflammation and the microcirculation. San Rafael, CA: Morgan & Claypool.
Furchgott, R. F., & Zawadzki, J. V. (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288(5789), 373–376.
Deanfield, J. E., Halcox, J. P., & Rabelink, T. J. (2007). Endothelial function and dysfunction: Testing and clinical relevance. Circulation, 115(10), 1285–1295.
Brownlee, M. (2001). Biochemistry and molecular cell biology of diabetic complications. Nature, 414(6865), 813–820.
Tooke, J. E. (1995). Microvascular function in human diabetes: A physiological perspective. Diabetes, 44(7), 721–726.
Levy, B. I., Schiffrin, E. L., Mourad, J. J., et al. (2001). Impaired tissue perfusion: A pathology common to hypertension, obesity, and diabetes mellitus. Circulation, 104(6), 735–740.
Camici, P. G., & Crea, F. (2007). Coronary microvascular dysfunction. New England Journal of Medicine, 356(8), 830–840.
Chade, A. R., & Lerman, A. (2006). Renovascular disease and the kidney microcirculation. Hypertension, 47(3), 286–293.
Vanhoutte, P. M., Shimokawa, H., Tang, E. H. C., & Feletou, M. (2009). Endothelial dysfunction and vascular disease. Acta Physiologica, 196(2), 193–222.