ROLE OF PORPHYROMONAS GINGIVALIS VIRULENCE FACTORS IN PERIODONTAL TISSUE DESTRUCTION
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Abstract:
The virulence factors of Porphyromonas gingivalis (P. gingivalis) play a pivotal role in the breakdown of periodontal tissues, making this pathogen central to understanding the pathogenesis of chronic periodontitis. Often described as a keystone pathogen, P. gingivalis has the unique ability to disrupt host immune responses, drive microbial dysbiosis, and cause extensive destruction of the tooth-supporting structures. Its major virulence determinants—including gingipains, lipopolysaccharides (LPS), and fimbriae—contribute significantly to disease progression by promoting inflammation, impairing host defenses, and degrading periodontal tissues.
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Moutsopoulos N.M., Konkel J.E. (2018). Tissue-specific immunity at the oral mucosal barrier. Trends in Immunology, 39(4), 276–287.
Byrne S.J., Dashper S.G., Darby I.B., Adams G.G., Hoffmann B., Reynolds E.C. (2009). Progression of chronic periodontitis can be predicted by the level of Porphyromonas gingivalis at baseline: a 2-year longitudinal study. Journal of Periodontology, 80(3), 425–431.
Olsen I., Yilmaz Ö. (2019). Novel mechanisms for microbial immune evasion. Periodontology 2000, 79(1), 152–160.
Aruni A.W., Dou Y., Mishra A., Fletcher H.M. (2015). The biofilm community: reconstructions, interactions, and role of extracellular subvesicles. Molecular Oral Microbiology, 30, 97–109.
Signat B., Roques C., Poulet P., Duffaut D. (2011). Fusobacterium nucleatum in periodontal health and disease. Current Issues in Molecular Biology, 13(2), 25–36.
Kebschull M., Demmer R.T., Papapanou P.N. (2010). “Gum bug, leave my heart alone!” — Epidemiologic and mechanistic links between periodontitis and cardiovascular disease. Journal of Dental Research, 89(9), 879–902.
Tonetti M.S., Van Dyke T.E. (2013). Periodontitis and atherosclerotic cardiovascular disease: consensus report. Journal of Clinical Periodontology, 40(S14), S24–S29.
Curtis M.A., et al. (2020). Pathobiology of periodontal disease: immune pathways to destruction and resolution. Journal of Dental Research, 99(1), 14–21.
Kumar P.S. (2017). Oral microbiota and systemic disease. Annals of Periodontology, 22(1), 1–12.
Mysak J., Podzimek S., Sommerova P., et al. (2014). Porphyromonas gingivalis: major periodontopathic pathogen overview. Journal of Immunology Research, 2014, 476068.
Belibasakis G.N. (2014). Microbiological and immune features of peri-implant diseases. Journal of Dental Research, 93(4), 326–333