EFFECTIVNESS AND SAFETY OF PROPHYLACTIC MEDICATION USE IN THE PERIOPERATIVE PERIOD
Main Article Content
Аннотация:
The perioperative period is a critical phase in surgical care, during which patients are at increased risk for complications such as infections, thromboembolic events, and excessive bleeding. Prophylactic medications, including antibiotics, anticoagulants, and analgesics, are widely used to prevent these adverse outcomes and improve overall patient safety. This article reviews current evidence regarding the effectiveness and safety of prophylactic medication use in the perioperative setting. Key considerations include appropriate drug selection, timing and dosing, patient-specific risk factors, and potential adverse effects. The findings indicate that carefully administered prophylactic therapy can significantly reduce postoperative complications, shorten hospital stays, and enhance recovery, while minimizing medication-related risks..
Article Details
Как цитировать:
Библиографические ссылки:
Berrios Torres SI, Umscheid CA, Bratzler DW, et al. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surg. 2017;152(8):784 791.
Evidence based guideline on perioperative infection prevention and antimicrobial prophylaxis.
Perioperative antibiotic prophylaxis has been shown to be an effective measure for preventing surgical site infections. European Centre for Disease Prevention and Control (ECDC) systematic review and guidance. Systematic Review and Evidence based Guidance on Perioperative Antibiotic Prophylaxis. EU Publications; 2013.
Systematic evidence and process indicators for effective perioperative antibiotic use.
Younis AT, El Kabbani AO, Al Kayyali NS, et al. An Observational Study of Perioperative Antibiotic Prophylaxis Use at a Major Quaternary Care and Referral Hospital in Saudi Arabia. Saudi J Anaesth. 2018;12(1):82 88.
Demonstrates real world compliance challenges and safety considerations in perioperative antibiotic use.
“Antibiotic prophylaxis in elective laparoscopic cholecystectomy: a narrative review of efficacy, safety, and antimicrobial stewardship.” Ann Med Surg (Lond). 2025.
Reviews efficacy and potential harms of perioperative antibiotic prophylaxis including resistance and safety.
Belated continuation of antibiotic prophylaxis after surgery shows no additional benefit in reducing surgical site infections: Systematic review and meta analysis. Global Guidelines for the Prevention of Surgical Site Infection. NCBI Bookshelf.
Provides evidence on optimal duration and safety of perioperative antibiotic regimens.
Appropriate perioperative antibiotic prophylaxis: challenges, strategies, and quality indicators. PubMed.
Summarizes compliance, best practices, and safety indicators in antibiotic PAP.
Clinical guideline review of perioperative medication management and chronic drug handling to improve safety in surgical patients. Guidelines on the Perioperative Management of Chronic Medication in Surgical Patients. PubMed. 2025.
Discusses safe perioperative handling of ongoing medications and prophylaxis considerations.
