TO STUDY THE STRUCTURE OF AVENACINE A-1 AND QUERCETINE USING IR-SPECTROSCOPIC AND QUANTUMCHEMICAL COMPUTATIONAL TECHNIQUES AND THEIR ANTIMYCOBACTERIAL ACTIVITY

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Abstract:

In the countries of the world, special attention is paid to the synthesis of new chemical compounds for medicine. Chemicals compound in the plant such as avenacine A-1, quercetin have the necessary pharmacological effects on the body and therefore act as a natural anti-tuberculosis agent.

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How to Cite:

Mamatova , I. . (2022). TO STUDY THE STRUCTURE OF AVENACINE A-1 AND QUERCETINE USING IR-SPECTROSCOPIC AND QUANTUMCHEMICAL COMPUTATIONAL TECHNIQUES AND THEIR ANTIMYCOBACTERIAL ACTIVITY. Eurasian Journal of Academic Research, 2(5), 713–721. Retrieved from https://in-academy.uz/index.php/ejar/article/view/3168

References:

Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).

Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181.

Hertog, M.G.; Hollman, P.C. Potential health effects of the dietary flavonol quercetin. Eur. J. Clin. Nutr. 1996,50, 63–71.

Carullo, G.; Perri, M.; Manetti, F.; Aiello, F.; Caroleo, M.C.; Cione, E. Quercetin-3-oleoyl derivatives as new GPR40 agonists: Molecular docking studies and functional evaluation. Bioorg. Med. Chem. Lett. 2019, 29, 1761–1764. [CrossRef] [PubMed]

Badolato, M.; Carullo, G.; Perri, M.; Cione, E.; Manetti, F.; Di Gioia, M.L.; Brizzi, A.; Caroleo, M.C.; Aiello, F. Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators. Fut. Med. Chem. 2017, 9, 1873–1885. [CrossRef] [PubMed]

Saponara, S.; Sgaragli, G.; Fusi, F. Quercetin as a novel activator of L-type Ca(2+) channels in rat tail artery smooth muscle cells. Br. J. Pharmacol. 2002, 135, 1819–1827.

Suriyanarayanan et al. 2013 Suriyanarayanan B, Shanmugam K, Santhosh RS (2013) Syntheticquercetin inhibits mycobacterial growth possibly by interacting with DNA gyrase. Rom Biotechnol Lett 18:1587–1593

Jacob et al. 2014 Jacob SJP, Jothivanan E, Vamsi BYV (2014) Molecular docking analysis of bioflavonoids against Mycobacterium tuberculosis drug target beta-ketoacyl-acp synthase III. Intern J Pharm Res Dev 6: 48–52

Shukla et al. 2015 Shukla H, Kumar V, Singh AK, Rastogi S, Khan SR, Siddiqi MI et al. (2015) Isocitratelyase of Mycobacterium tuberculosis is inhibited by quercetin through binding at Nterminus. Intern J Biol Macromol 78: 137–41).

C. N. Armah,* A. R. Mackie,* The Membrane-Permeabilizing Effect of Avenacin A-1 Involves the Reorganization of Bilayer Cholesterol Biophysical Journal Volume 76 January 1999 р-281–290

Э.В.Гелла, Л.В.Шатунова и В.А.Бирюк/ A.c. 701640 СССР. Способ получения кверцетина/. Опубл. 05.12.79. Бюл. № 45

J. V. Maizel, H J Burkhardt, H K Mitchell Avenacin, an antimicrobial substance isolated from avena sativa. I. Isolation and antimicrobial activity./ Biochemistry 1964 Mar;3:424-6. doi: 10.1021/bi00891a020.

Ribeiro et al., 2011 Turner EMC. 1960 The nature of the resistance of oats to the take-all fungus. Distribution of the inhibitor in oat seedlings. Journal of Experimental Botany 11: 403–412

Mamatova, I., Askarov, I., & Mamarakhmonov, M. (2020). Antituberculosis, Antimicrobic and Antioxidant Properties of Persica Vulgaris L. Extracts. Biomedical Chemistry: Research and Methods, 3(2), e00125. https://doi.org/10.18097/BMCRM00125