PATHOGENESIS OF APICAL PROLAPSE: THE ROLE OF CONNECTIVE TISSUE DYSPLASIA AND GENETIC FACTORS

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Issue: Vol. 5 No. 10 : Eurasian Journal of Academic Research
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доктор медицинских наук, профессор, заведующая кафедрой акушерства и гинекологии №1 Самаркандского государственного медицинского университета
info@in-academy.uz
соискатель, врач акушер-гинеколог Джизакского филиала Республиканского специализированного научно-практического центра здоровья матери и ребенка
info@in-academy.uz

Abstract:

Apical genital prolapse is a complex form of pelvic organ prolapse, the pathogenesis of which is closely linked to congenital connective tissue disorders and genetic factors. The objective of this review is to summarize current data on the molecular mechanisms of pelvic floor weakness, including changes in collagen metabolism, matrix metalloproteinase (MMP) activity, tissue inhibitors of pelvic organ prolapse (TIMP), and mutations in the COL1A1 and COL3A1 genes. This paper utilizes data from international studies, publications published between 2015 and 2024, and current international guidelines (ACOG, AUGS, FIGO).

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Худоярова , Д., & Мухаммадиева , С. . (2025). PATHOGENESIS OF APICAL PROLAPSE: THE ROLE OF CONNECTIVE TISSUE DYSPLASIA AND GENETIC FACTORS. Eurasian Journal of Academic Research, 5(10), 239–242. Retrieved from https://in-academy.uz/index.php/ejar/article/view/63295

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