SUT BEZI SARATONI: EPIDEMIOLOGIYA, MOLEKULYAR XUSUSIYATLAR VA GENETIK ASOSLAR
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Аннотация:
Sut bezi saratoni global miqyosda ayollar orasida eng ko‘p uchraydigan onkologik kasalliklardan biri bo‘lib, uning rivojlanishi epidemiologik, biologik va genetik omillarning murakkab o‘zaro ta’siri bilan tavsiflanadi. Ushbu tezisda sut bezi saratonining global va mintaqaviy epidemiologiyasi, yoshga bog‘liq xususiyatlari, molekulyar subtiplari hamda irsiy moyillik bilan bog‘liq asosiy genetik omillar tahlil qilindi. Xususan, BRCA1 va BRCA2 genlaridagi patogen variantlarning kasallik patogenezidagi o‘rni, klinik ahamiyati va davolash strategiyalarini tanlashdagi roli yoritildi. Shuningdek, keyingi avlod sekvenslash (NGS) texnologiyalarining aniqlik tibbiyotidagi ahamiyati, sut bezi saratonini tashxislash, prognozlash va individual davolash yondashuvlarini shakllantirishdagi imkoniyatlari muhokama qilindi. Ushbu sharh natijalari populyatsion genomika va molekulyar diagnostikani klinik amaliyotga keng joriy etish sut bezi saratoni bilan bog‘liq kasallanish va o‘lim ko‘rsatkichlarini kamaytirishga xizmat qilishi mumkinligini ko‘rsatadi.
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