Центральноазиатский журнал междисциплинарных исследований и исследований в области управления

Ushbu ilmiy ish tirik organizm to‘qimalarining qo‘zg‘aluvchanlik xususiyatlarini va ularning fiziologik mexanizmlarini yoritishga bag‘ishlangan. Maqolada nerv, mushak va bez to‘qimalarining qo‘zg‘aluvchanlik darajasi, ularning tashqi va ichki ta’sirotlarga javob berish mexanizmlari batafsil tahlil qilingan. Qo‘zg‘alish jarayonida hujayralarda modda va energiya almashinuvi kuchayishi, kislorod sarfining ortishi hamda karbonat angidrid va issiqlik ajralishining ko‘payishi ilmiy asosda tushuntirilgan. Shuningdek, hujayra membranasida yuzaga keladigan bioelektrik hodisalar  tinchlik potensiali va harakat potensialining shakllanishi, ion asimmetriyasi hamda natriy va kaliy ionlarining membrana orqali harakati yoritib berilgan. Qo‘zg‘alish jarayonining tarqalishi, uning qisqa vaqt ichida yuzaga kelishi va fiziologik ahamiyati ko‘rsatib o‘tilgan. Bundan tashqari, qo‘zg‘aluvchanlikni baholash mezonlari bo‘lgan reobaza va xronaksiyaning nazariy hamda amaliy ahamiyati ochib berilgan. Absolyut refrakterlik holati va uning yurak faoliyatidagi namoyon bo‘lishi misolida qo‘zg‘aluvchanlikning fiziologik cheklanishlari tahlil qilingan.

Mikrotsirkulyatsiya — bu organizmdagi eng nozik qon tomirlari tarmog‘i bo‘lib, arteriolalar, kapillyarlar va venulalardan iborat. U organ va to‘qimalarga kislorod, glyukoza, aminokislotalar va boshqa oziqa moddalarini yetkazish hamda metabolik chiqindilarni olib chiqishda asosiy rol o‘ynaydi. Mikrotsirkulyatsiya buzilishi turli ichki a’zolarda patofiziologik jarayonlarning rivojlanishiga bevosita ta’sir ko‘rsatadi. Shu jumladan, qandli diabet, gipertenziya, yurak-qon tomir kasalliklari, buyrak yetishmovchiligi va boshqa surunkali patologiyalarda mikroangiopatiya, endotelial disfunktsiya va kapillyar perfuziya buzilishi aniqlanadi. Ushbu maqolada mikrotsirkulyatsiya buzilishining mexanizmlari, uning ichki a’zolar kasalliklari patogenezidagi roli, bemorlar orasida kuzatilgan klinik belgilar va laboratoriya ko‘rsatkichlari tahlil qilinadi. Shuningdek, turli kasalliklar kontekstida mikrotsirkulyatsiyani normallashtirishning profilaktik va terapevtik yondashuvlari ham ko‘rib chiqiladi. Mikrotsirkulyatsiya buzilishining o‘rganilishi ichki a’zolar kasalliklarini erta tashxislash, asoratlarning oldini olish va davolash strategiyalarini optimallashtirish uchun zarurdir.

мазкур мақолада ОИВ ва таносил касалликларини тарқатиш билан боғлиқ жиноятларни аниқлаш ва тергов қилишда катта ҳажмдаги маълумотлар (Big Data) ва геоахборот тизимларидан фойдаланиш истиқболлари тадқиқ этилади. Муаллиф "рақамли эпидемиология" усуллари орқали касаллик тарқалишининг аномал ўсиш нуқталарини аниқлаш ва "супер-тарқатувчи" шахсларни кибертергов воситалари ёрдамида аниқлаш механизмини асослайди. Мақолада Ўзбекистонда миллий аноним филогенетик базани яратиш ва уни тергов органларининг рақамли тизимлари билан интеграция қилиш бўйича инновацион таклифлар берилган.

Ушбу мақолада ОИВ ва таносил касалликларини тарқатиш жиноятларини тергов қилишда вақт омилининг криминалистик аҳамияти тадқиқ этилади. Муаллиф вирус геномининг мутацияга учраш тезлигига асосланган “молекуляр соат” концепциясини жиноят-процессуал исботлаш жараёнига татбиқ этиш масалаларини илмий асослаб беради. Рақамли хронологик регрессия моделлари орқали жиноят содир этилган “эҳтимолий вақт дарчаси”ни аниқлаш методикаси таклиф этилган.

Bachadon miomasi (leiomioma) ayollarda eng ko‘p uchraydigan yaxshi sifatli o‘sma hisoblanib, reproduktiv va perimenopauzal yoshda keng tarqalgan. Ushbu tadqiqot bachadon miomasi bilan og‘rigan ayollarda kasallikning klinik kechishi, asosiy simptomlari, tashxis qo‘yish usullari hamda zamonaviy davolash yondashuvlarining samaradorligini baholashga bag‘ishlangan. Tadqiqot natijalari miomani erta aniqlash va individual davolash taktikasini tanlash ayollarning hayot sifatini yaxshilashda muhim ahamiyatga ega ekanligini ko‘rsatdi.

Мақолада вояга етмаган шахсларга қарши жинсий жиноятларни тергов қилишнинг назарий ва амалиёт жиҳатлари таҳлил қилиниб, ҳуқуқни қўллаш амалиёти ва қонунчиликдаги коллизион ҳолатлар батафсил очиб берган ҳамда уларни бартараф этишга қаратилган асосий таклиф ва тавсиялар ишлаб чиқилган.

В статье исследуются современные инновационные подходы к развитию региональной инфраструктуры на основе внедрения технологий искусственного интеллекта (ИИ) в условиях социально-экономического развития Республики Узбекистан. Рассматриваются экономические эффекты применения ИИ, включая снижение эксплуатационных расходов, повышение эффективности использования ресурсов, рост инвестиционной привлекательности регионов и улучшение качества инфраструктурных услуг. Приведен сравнительный анализ ключевых показателей до и после внедрения интеллектуальных технологий, демонстрирующий значительное повышение производительности и надежности инфраструктуры, а также формирование новых рабочих мест и повышение доходов населения.

Insulin resistance, abdominal obesity, dyslipidemia, and hypertension are among the many interrelated risk factors that define metabolic syndrome, a complex metabolic disease. Together, these factors put people at higher risk for T2DM and CVD). Globally, metabolic syndrome has become more common as obesity and sedentary lifestyles have increased. The pathophysiology of metabolic syndrome is examined in this review, with a focus on how it contributes to the onset and advancement of T2DM and CVD. The significant public health burden that metabolic syndrome poses is shown by epidemiological statistics, which calls for efficient care and prevention measures. The usefulness of the existing screening instruments and diagnostic criteria in clinical practice is highlighted. Management methods encompass lifestyle adjustments, medication, and surgical therapies, each targeting distinct components of metabolic syndrome to decrease cardiovascular and metabolic risks. Emerging research directions to improve prevention and treatment outcomes are discussed along with the difficulties in detecting and treating metabolic syndrome. This study attempts to help healthcare professionals optimize patient care and advance public health measures to combat this prevalent syndrome by clarifying the complex link between metabolic syndrome, CVD, and type 2 diabetes. Metabolic syndrome stands alone as a risk factor for numerous adverse health consequences. To lower cardiovascular risk and avoid diabetes and its complications, each of its constituent parts should be managed with medication and behavioral modifications. The treatment of the illness itself requires further investigation. Although more research is required on how to treat metabolic syndrome as opposed to its components, a diagnosis of the condition may be helpful in encouraging patients to make lifestyle adjustments.

About one in four people worldwide suffer from iron ID, the most common micronutrient deficiency. Children, women of reproductive age, and those living in low- and middle-income nations are disproportionately affected. With effects ranging from decreased physical performance and quality of life in adults to increased risks during pregnancy, including low birth weight, preterm delivery, and maternal mortality, as well as impaired cognitive and motor development in children, it substantially adds to the global burden of disease. Though clinical and functional abnormalities, including exhaustion, immunological dysfunction, and cognitive deficiencies, can happen even in the absence of anemia, ID frequently occurs before IDA. According to the World Health Organization, iron deficiency anemia (IDA) affects 30% of the population worldwide, making it the most prevalent dietary deficiency. Reduced dietary iron and decreased iron absorption are additional contributing factors to IDA, even though gastrointestinal bleeding and women's menstruation are the most frequent causes. Restoring iron reserves and bringing hemoglobin levels back to normal should be the goals of treatment for patients with IDA. This has been demonstrated to enhance pregnancy outcomes, morbidity, quality of life, and the prognosis for chronic illnesses. Numerous chronic inflammatory diseases, such as inflammatory bowel disease, chronic kidney disease, and congestive heart failure, are associated with iron deficiency. An updated summary of the diagnosis and treatment of IDA in patients with chronic illnesses, both before and during pregnancy, will be given in this article. Along with a summary of the cost comparison of the various iron formulations now available on the market, we will go over the advantages and disadvantages of oral versus intravenous iron replacement in each group. 

this article under discussion deals with English language teaching through games. Utilizing games in classroom can fulfill the essential aim of teaching, which to make students active participants in the learning process and keep them motivated. Moreover, this games can develop sense of creativity and curiosity. Nowadays, games are main section of English language learning. One of the pros of the games is all students work simultaneously. The utilization of numerous games helps to attract children to a foreign language, creates conditions for success in language learning. And students who want to play, will definitely want to improve their knowledge of a foreign language.

This article examines the psychological factors influencing lexical selection,comparing native Uzbek and English speakers. It explores how cognitive, affective, and sociocultural dimensions—including linguistic relativity, emotional valence, social context, and cultural schemas—differentially shape word choice in these distinct language systems. The study employs a framework integrating psycholinguistics, cognitive linguistics, and sociolinguistics to analyze empirical data from verbal tasks and discourse analysis. Key findings reveal that Uzbek speakers' word selection is strongly guided by social hierarchy, formality distinctions, and collectivist cultural values, whereas English speakers exhibit greater emphasis on individualism, directness, and emotional expression. The article contributes to understanding the psychological interface between language, thought, and culture and offers practical implications for cross-cultural communication, language teaching, and translation.

Мазкур мақолада ҳудудларда жиноятчиликни олдини олиш жараёнида қонун устуворлигини таъминлаш чораларининг назарий-ҳуқуқий ва амалий жиҳатлари комплекс таҳлил қилинган. Жиноятларни ҳисобга олишда шаффофликни таъминлаш, жиноят ишини қўзғатишни асоссиз рад этиш ҳолатларига барҳам бериш, мурожаатларни мажбурий рўйхатга олиш, рақамли мониторинг тизимларини жорий этиш ҳамда жамоатчилик назоратини кучайтириш каби механизмлар қонун устуворлигининг институционал кафолатлари сифатида асослаб берилган. Шунингдек, электрон ахборот тизимлари, мобил иловалар ва интеграциялашган маълумотлар базалари орқали жиноятчилик профилактикасини кучайтириш масалалари илмий манбалар ва расмий статистик маълумотлар асосида ёритилган. Тадқиқот натижалари қонун устуворлигини таъминлаш жиноятчиликни барқарор камайтиришнинг асосий шарти эканини кўрсатади.