LIPIDLARNI PEROKSIDLANISHI VA HUJAYRA SHIKASTLANISHI POTOGENEZIDAGI AHAMIYATI
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Abstract:
Lipidlarning proksidlanishi (lipid peroksidlanishi) hujayralarda erkin radikallar ta’sirida sodir bo‘ladigan oksidlovchi jarayon bo‘lib, u biologik membranalarning strukturaviy yaxlitligini buzadi. Ushbu jarayon natijasida hosil bo‘ladigan reaktiv kislorod turlari va lipid peroksid mahsulotlari hujayra oqsillari, DNK va ferment tizimlariga zarar yetkazadi. Lipid peroksidlanishining ortishi oksidlovchi stress, yallig‘lanish, ateroskleroz, neyrodegenerativ kasalliklar va saraton patogenezida muhim rol o‘ynaydi. Shu sababli, antioksidant himoya tizimining faolligi va uning yetishmovchiligi organizmda hujayra shikastlanishi darajasini belgilovchi asosiy omillardan biridir
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Zaxarov V.B..Mamatov S.G.,So-n i i V.I., Obshaya biologiya. M., 2002; Ch ye n -sov Yu.S., Obshaya sitologiya, M., 1984; Grin N., Staut U., Teylor D., Biologiya, t. 1—3. M., 1990; M avlonov O., Biologiya (Maʼlumotnoma|, T., 2003.
Halliwell B., Gutteridge J.M.C. Free Radicals in Biology and Medicine. – Oxford University Press, 2015.
Ayala A., Muñoz M.F., Argüelles S. Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxidative Medicine and Cellular Longevity, 2014.
Valko M., Leibfritz D., Moncol J., Cronin M.T., Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry & Cell Biology, 2007.
Жданов В.Д. Биохимия оксидативного стресса. – Москва: Наука, 2018.
Мухаммадиева Д.М. Oksidlovchi stress va antioksidant himoya tizimining ahamiyati. Tibbiyot va hayot jurnali, 2021, №3.