ALLERGIK KASALLIKLARDA FENOTIPLARNING O’RNI
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Аннотация:
Allergik kasalliklarning rivojlanishiga sabab bo'lgan sabablarning xilma-xilligi, murakkab patogenezi va bemorlarning terapiyaga teng bo'lmagan javoblari allergik kasalliklarning fenotiplari va endotiplarini aniqlash uchun asos bo'ldi. Ushbu muammoga bo'lgan bunday yuqori qiziqish allergik kasalliklarni tashxislash va davolashdagi zamonaviy yutuqlar har doim ham bemorlarni qoniqtirmasligi va ularning ko'pchiligi standart davolashning samarasizligini boshdan kechirayotganligi bilan izohlanadi. Har bir fenotipning o'ziga xos molekulyar markerlari (endotiplari) mavjud bo'lib, ular keyingi dekodlashni talab qiladi. Ota-onadan olingan xromosomalar majmui, umuman olganda, ma'lum bir turga va xususan, ma'lum bir organizmga xos bo'lgan genlar to'plamini o'z ichiga oladi. Allergenga xos immunoterapiya kabi patogenetik davolanishga kelsak, u hali klinik amaliyotda keng qo'llanilishini topmagan. Ushbu turdagi immunoterapiyani o'tkazishning turli usullari taklif qilingan: og'iz, teri osti va boshqalar, ammo uning oziq-ovqat allergiyalari uchun mosligi masalasi qo'shimcha o'rganishni talab qiladi.
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