AN OVERVIEW OF ALZHEIMER’S DISEASE THERAPIES AND THEIR CLINICAL LIMITATIONS
Article Sidebar
Main Article Content
Аннотация:
Neurodegenerative diseases (NDs) represent a growing global health challenge, driven by an aging population, modern lifestyle factors, increasing prevalence, and the substantial physical, emotional, and financial burdens placed on patients, caregivers, and healthcare systems. Currently, over 50 million individuals worldwide are affected by NDs, and this figure is projected to nearly triple to 152 million by 2050 if no effective preventive or therapeutic measures are developed. Among these disorders, Alzheimer’s disease (AD) is the most prevalent, accounting for approximately 60% to 80% of all neurodegenerative cases.
Article Details
Как цитировать:
Библиографические ссылки:
Scheltens, P.; Blennow, K.; Breteler, M.M.B.; de Strooper, B.; Frisoni, G.B.; Salloway, S.; Van der Flier, W.M. Alzheimer’s Disease. Lancet 2016, 388, 505–517. [Google Scholar] [CrossRef]
Prince, M.J. World Alzheimer Report 2015: The Global Impact of Dementia. Available online: https://www.alz.co.uk/research/world-report-2015 (accessed on 7 March 2019).
Livingston, G.; Huntley, J.; Sommerlad, A.; Ames, D.; Ballard, C.; Banerjee, S.; Brayne, C.; Burns, A.; Cohen-Mansfield, J.; Cooper, C.; et al. Dementia Prevention, Intervention, and Care: 2020 Report of the Lancet Commission. Lancet 2020, 396, 413–446. [Google Scholar] [CrossRef]
Alzheimer’s Association. 2018 Alzheimer’s Disease Facts and Figures. Alzheimer’s Dement. 2018, 14, 367–429. [Google Scholar] [CrossRef]
Thal, D.R.; Rüb, U.; Orantes, M.; Braak, H. Phases of Aβ-Deposition in the Human Brain and Its Relevance for the Development of AD. Neurology 2002, 58, 1791–1800. [Google Scholar] [CrossRef] [PubMed]
Braak, H.; Braak, E. Neuropathological Stageing of Alzheimer-Related Changes. Acta Neuropathol. 1991, 82, 239–259. [Google Scholar] [CrossRef]
Knopman, D.S.; Amieva, H.; Petersen, R.C.; Chételat, G.; Holtzman, D.M.; Hyman, B.T.; Nixon, R.A.; Jones, D.T. Alzheimer Disease. Nat. Rev. Dis. Prim. 2021, 7, 33. [Google Scholar] [CrossRef]
Wang, Z.-X.; Tan, L.; Liu, J.; Yu, J.-T. The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease. Mol. Neurobiol. 2016, 53, 1905–1924. [Google Scholar] [CrossRef]